STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AEB12280.1COGs: COG0337 3-dehydroquinate synthetase; HAMAP: 3-dehydroquinate synthase AroB, subgroup; InterPro IPR002658:IPR016037; KEGG: mrb:Mrub_2746 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase AroB; PRIAM: 3-dehydroquinate synthase; SPTR: 3-dehydroquinate synthase; IMG reference gene:2504661151; PFAM: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase. (342 aa)    
Predicted Functional Partners:
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
  
 0.999
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 0.996
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
 
 0.996
AEB10882.1
Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterProIPR010954:IPR006268:IPR002701:IPR020822:IPR 006218; KEGG: ttj:TTHA0388 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; PFAM: DAHP synthetase I/KDSA; Chorismate mutase, type II; SMART: Chorismate mutase; SPTR: Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; Chorismate mutase, Gram-positive bacteria/Deinococcus; IMG reference gene:2504659686; PFAM: Chorismate mutase type II; DAHP [...]
 
 
 0.993
AEB11887.1
Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218; KEGG: opr:Ocepr_1189 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; IMG reference gene:2504660737; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase.
 
 
 0.986
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.985
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 0.980
AEB12282.1
COGs: COG4122 O-methyltransferase; InterPro IPR002935; KEGG: rmr:Rmar_2512 O-methyltransferase family 3; PFAM: O-methyltransferase, family 3; SPTR: Putative O-methyltransferase mdmC; IMG reference gene:2504661153; PFAM: O-methyltransferase.
    
 0.823
AEB11886.1
COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099:IPR002912; KEGG: opr:Ocepr_1190 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; Amino acid-binding ACT; PRIAM: Prephenate dehydrogenase; SPTR: Prephenate dehydrogenase; IMG reference gene:2504660736; PFAM: Prephenate dehydrogenase; ACT domain.
 
  
 0.775
AEB11729.1
Glutamine amidotransferase of anthranilate synthase; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR006221:IPR015890:IPR000991; KEGG: msv:Mesil_3523 aminotransferase class IV; PFAM: Chorismate binding, C-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Anthranilate synthase; SPTR: Aminotransferase class IV; TIGRFAM: Anthranilate synthase, glutamine amidotransferase domain; IMG reference gene:2504660575; PFAM: Glutamine amidotransferase class-I; Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: glut [...]
 
  
 0.733
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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