node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEB10767.1 | AEB10934.1 | Marky_0002 | Marky_0171 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | 0.998 |
AEB10767.1 | AEB11320.1 | Marky_0002 | Marky_0569 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013:IPR011708:IPR004365:IPR004805:IPR 003141; KEGG: opr:Ocepr_1852 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III subunit alpha; TIGRFAM: DNA polymerase III, alpha subunit; IMG reference gene:2504660155; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; TIGRFAM: DNA-directed DNA polymerase III (polc). | 0.991 |
AEB10767.1 | AEB12324.1 | Marky_0002 | Marky_1589 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR005790; KEGG: msv:Mesil_2524 DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; IMG reference gene:2504661197; PFAM: DNA polymerase III subunits gamma and tau domain III; DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit. | 0.991 |
AEB10767.1 | AEB12387.1 | Marky_0002 | Marky_1652 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Transcriptional regulator domain-containing protein; InterPro IPR001867; KEGG: msv:Mesil_2972 hypothetical protein; PFAM: Signal transduction response regulator, C-terminal; SPTR: Putative uncharacterized protein; IMG reference gene:2504661261. | 0.924 |
AEB10767.1 | dnaX | Marky_0002 | Marky_2165 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.994 |
AEB10767.1 | polA | Marky_0002 | Marky_1136 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.998 |
AEB10767.1 | recA | Marky_0002 | Marky_0337 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.910 |
AEB10767.1 | sbcD | Marky_0002 | Marky_1322 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.590 |
AEB10767.1 | topA | Marky_0002 | Marky_0110 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.725 |
AEB10934.1 | AEB10767.1 | Marky_0171 | Marky_0002 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.998 |
AEB10934.1 | AEB11320.1 | Marky_0171 | Marky_0569 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013:IPR011708:IPR004365:IPR004805:IPR 003141; KEGG: opr:Ocepr_1852 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III subunit alpha; TIGRFAM: DNA polymerase III, alpha subunit; IMG reference gene:2504660155; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; TIGRFAM: DNA-directed DNA polymerase III (polc). | 0.864 |
AEB10934.1 | AEB12324.1 | Marky_0171 | Marky_1589 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR005790; KEGG: msv:Mesil_2524 DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; IMG reference gene:2504661197; PFAM: DNA polymerase III subunits gamma and tau domain III; DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit. | 0.681 |
AEB10934.1 | AEB12387.1 | Marky_0171 | Marky_1652 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | Transcriptional regulator domain-containing protein; InterPro IPR001867; KEGG: msv:Mesil_2972 hypothetical protein; PFAM: Signal transduction response regulator, C-terminal; SPTR: Putative uncharacterized protein; IMG reference gene:2504661261. | 0.989 |
AEB10934.1 | dnaX | Marky_0171 | Marky_2165 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.840 |
AEB10934.1 | polA | Marky_0171 | Marky_1136 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.999 |
AEB10934.1 | recA | Marky_0171 | Marky_0337 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.993 |
AEB10934.1 | sbcD | Marky_0171 | Marky_1322 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.998 |
AEB10934.1 | topA | Marky_0171 | Marky_0110 | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.997 |
AEB11320.1 | AEB10767.1 | Marky_0569 | Marky_0002 | COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013:IPR011708:IPR004365:IPR004805:IPR 003141; KEGG: opr:Ocepr_1852 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III subunit alpha; TIGRFAM: DNA polymerase III, alpha subunit; IMG reference gene:2504660155; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; TIGRFAM: DNA-directed DNA polymerase III (polc). | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.991 |
AEB11320.1 | AEB10934.1 | Marky_0569 | Marky_0171 | COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013:IPR011708:IPR004365:IPR004805:IPR 003141; KEGG: opr:Ocepr_1852 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III subunit alpha; TIGRFAM: DNA polymerase III, alpha subunit; IMG reference gene:2504660155; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; TIGRFAM: DNA-directed DNA polymerase III (polc). | ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...] | 0.864 |