STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB12482.1ABC-type transporter, integral membrane subunit; COGs: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system permease component; InterPro IPR000515; KEGG: bav:BAV1989 ABC transporter, permease protein; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: ABC transporter, permease protein; IMG reference gene:2504661356; PFAM: Binding-protein-dependent transport system inner membrane component. (251 aa)    
Predicted Functional Partners:
AEB12483.1
Taurine-transporting ATPase; COGs: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: psa:PST_1824 ABC transporter ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Taurine-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Aliphatic sulfonates ABC superfamily ATP binding cassette transporter, ABC protein; IMG reference gene:2504661357; PFAM: ABC transporter.
  
 0.997
AEB12484.1
ABC transporter substrate-binding protein; COGs: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components; InterPro IPR015168; KEGG: azl:AZL_a01120 ABC transporter substrate-binding protein; SPTR: ABC transporter substrate-binding protein; IMG reference gene:2504661358; PFAM: NMT1/THI5 like.
 
  
 0.993
AEB12481.1
Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR013749:IPR004399; KEGG: ttj:TTHA0680 phosphomethylpyrimidine kinase (ThiD); PFAM: Phosphomethylpyrimidine kinase type-1; PRIAM: Phosphomethylpyrimidine kinase; SPTR: Phosphomethylpyrimidine kinase (ThiD); TIGRFAM: Phosphomethylpyrimidine kinase type-2; IMG reference gene:2504661355; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
       0.655
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
     
 0.645
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
    0.637
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
       0.634
AEB12477.1
Thiamine biosynthesis protein ThiS; InterPro IPR003749:IPR010035; KEGG: ttj:TTHA0675 putative thiamine biosynthesis protein ThiS; PFAM: ThiamineS; SPTR: Putative thiS protein; TIGRFAM: ThiS, thiamine-biosynthesis; IMG reference gene:2504661351; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
       0.628
AEB12479.1
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: ttj:TTHA0677 putative oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: Putative oxidoreductase; IMG reference gene:2504661353; PFAM: FAD dependent oxidoreductase.
  
    0.617
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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