STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa)    
Predicted Functional Partners:
pgi
COGs: COG0166 Glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); InterPro IPR001672; KEGG: mrb:Mrub_2801 phosphoglucose isomerase (PGI); PFAM: Phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; IMG reference gene:2504661569; PFAM: Phosphoglucose isomerase; Belongs to the GPI family.
  
 0.988
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
   
  
 0.981
AEB10769.1
COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015795; KEGG: opr:Ocepr_0004 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; IMG reference gene:2504659566; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
 
 0.953
AEB11562.1
Transketolase; COGs: COG0021 Transketolase; InterPro IPR005478:IPR005475:IPR005474:IPR005476; KEGG: opr:Ocepr_1662 transketolase; PFAM: Transketolase, N-terminal; Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: Formaldehyde transketolase; SMART: Transketolase-like, pyrimidine-binding domain; SPTR: Transketolase; TIGRFAM: Transketolase, bacterial-like; IMG reference gene:2504660404; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; TIGRFAM: transketolase, bacterial and ye [...]
  
 
 0.934
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.931
AEB12213.1
Fructose-1,6-bisphosphatase, class II; COGs: COG1494 Fructose-1 6-bisphosphatase/sedoheptulose 1 7-bisphosphatase and related protein; InterPro IPR004464; KEGG: opr:Ocepr_1301 fructose-1,6-bisphosphatase, class II; PFAM: Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase; PRIAM: Fructose-bisphosphatase; SPTR: Fructose-1,6-bisphosphatase, class II; TIGRFAM: Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase; IMG reference gene:2504661081; PFAM: Bacterial fructose-1,6-bisphosphatase, glpX-encoded; TIGRFAM: fructose-1,6-bisphosphatase, class II.
   
 
 0.929
AEB12567.1
COGs: COG1482 Phosphomannose isomerase; InterPro IPR001250; KEGG: mrb:Mrub_2255 mannose-6-phosphate isomerase; PFAM: Mannose-6-phosphate isomerase, type I; PRIAM: Mannose-6-phosphate isomerase; SPTR: Mannose-6-phosphate isomerase; IMG reference gene:2504661448; PFAM: Phosphomannose isomerase type I.
 
  
 0.927
fbp
Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
    
 0.913
AEB11649.1
Fructokinase; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611; KEGG: sil:SPOA0276 fructokinase; PFAM: Carbohydrate/purine kinase; PRIAM: Fructokinase; SPTR: Fructokinase; IMG reference gene:2504660492; PFAM: pfkB family carbohydrate kinase.
  
 
 0.913
AEB10998.1
COGs: COG3684 Tagatose-1 6-bisphosphate aldolase; InterPro IPR002915; KEGG: cag:Cagg_3347 tagatose 1,6-diphosphate aldolase; PFAM: Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Tagatose-bisphosphate aldolase; IMG reference gene:2504659808; PFAM: DeoC/LacD family aldolase; TIGRFAM: tagatose 1,6-diphosphate aldolase.
    
 0.908
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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