STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
AEB12587.12-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa)    
Predicted Functional Partners:
AEB12586.1
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR005475:IPR011603:IPR001017; KEGG: msv:Mesil_1943 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component; PRIAM: Oxoglutarate dehydrogenase (succinyl-transferring); SMART: Transketolase-like, pyrimidine-binding domain; SPTR: 2-oxoglutarate dehydrogenase, E1 subunit; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component; IMG reference gene:2504661468; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxog [...]
 0.999
AEB12588.1
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR006258:IPR013027:IPR004099; KEGG: tra:Trad_0899 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; IMG reference gene:2504661470; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: di [...]
 0.999
AEB11457.1
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR006258:IPR013027:IPR004099; KEGG: msv:Mesil_1132 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; IMG reference gene:2504660295; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: d [...]
 0.989
AEB11459.1
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: opr:Ocepr_1751 transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); SMART: Transketolase-like, pyrimidine-binding domain; SPTR: Transketolase central region; IMG reference gene:2504660297; PFAM: Transketolase, C-terminal domain; [...]
 0.978
sucC
Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.976
AEB11975.1
COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: msv:Mesil_1851 transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: Pyruvate dehydrogenase (acetyl-transferring); SMART: Transketolase-like, pyrimidine-binding domain; SPTR: Transketolase central region; IMG reference gene:2504660829; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
 0.973
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.967
AEB11447.1
2-oxoacid:acceptor oxidoreductase, alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR022367:IPR002880; KEGG: ttj:TTHA1955 2-oxoacid--ferredoxin oxidoreductase, alpha chain; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoacid--ferredoxin oxidoreductase, alpha chain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; IMG reference gene:2504660285; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:accept [...]
     
 0.936
AEB12323.1
COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR006092:IPR006091:IPR006090; KEGG: opr:Ocepr_0707 acyl-CoA dehydrogenase domain-containing protein; PFAM: Acyl-CoA dehydrogenase, N-terminal; Acyl-CoA oxidase/dehydrogenase, central domain; Acyl-CoA oxidase/dehydrogenase, type 1; PRIAM: Glutaryl-CoA dehydrogenase; SPTR: Acyl-CoA dehydrogenase domain protein; IMG reference gene:2504661196; PFAM: Acyl-CoA dehydrogenase, C-terminal domain; Acyl-CoA dehydrogenase, middle domain; Acyl-CoA dehydrogenase, N-terminal domain.
   
 0.912
AEB11446.1
COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011896:IPR011766; KEGG: tth:TTC1592 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoacid-ferredoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; IMG reference gene:2504660284; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domai [...]
   
 
 0.910
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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