STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
AEB12666.1TENA/THI-4 domain-containing protein; InterPro IPR004305; KEGG: opr:Ocepr_0007 transcriptional activator, TenA family; PFAM: TENA/THI-4 protein/Coenzyme PQQ biosynthesis protein C; SPTR: Transcriptional activator, TenA family; IMG reference gene:2504661550; PFAM: TENA/THI-4/PQQC family. (206 aa)    
Predicted Functional Partners:
Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR013749:IPR004399; KEGG: ttj:TTHA0680 phosphomethylpyrimidine kinase (ThiD); PFAM: Phosphomethylpyrimidine kinase type-1; PRIAM: Phosphomethylpyrimidine kinase; SPTR: Phosphomethylpyrimidine kinase (ThiD); TIGRFAM: Phosphomethylpyrimidine kinase type-2; IMG reference gene:2504661355; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
Von Willebrand factor type A; COGs: COG4867 Uncharacterized protein with a von Willebrand factor type A (vWA) domain; InterPro IPR002035; KEGG: ttj:TTHA0637 hypothetical protein; SMART: von Willebrand factor, type A; SPTR: Hypothetical cytosolic protein; IMG reference gene:2504661548.
KEGG: msv:Mesil_1091 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504661549.
COGs: COG1239 Mg-chelatase subunit ChlI; KEGG: mrb:Mrub_2429 magnesium protoporphyrin chelatase putative; SPTR: Magnesium protoporphyrin chelatase, putative; IMG reference gene:2504661547; PFAM: Sigma-54 interaction domain.
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR007901; KEGG: opr:Ocepr_0973 uba/ThiF-type nad/fad binding protein; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: Molybdopterin biosynthesis moeB protein; IMG reference gene:2504660659; PFAM: MoeZ/MoeB domain; ThiF family.
thiamineS protein; InterPro IPR003749; KEGG: ttj:TTHA0476 hypothetical protein; PFAM: ThiamineS; SPTR: Putative uncharacterized protein; IMG reference gene:2504660060; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
Thiamine biosynthesis protein ThiS; InterPro IPR003749:IPR010035; KEGG: ttj:TTHA0675 putative thiamine biosynthesis protein ThiS; PFAM: ThiamineS; SPTR: Putative thiS protein; TIGRFAM: ThiS, thiamine-biosynthesis; IMG reference gene:2504661351; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
Lactate utilization protein B/C; COGs: COG1556 conserved hypothetical protein; InterPro IPR003741; KEGG: msv:Mesil_1094 protein of unknown function DUF162; PFAM: Domain of unknown function DUF162; SPTR: Putative uncharacterized protein; IMG reference gene:2504661546; PFAM: Uncharacterised ACR, YkgG family COG1556.
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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