STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (649 aa)    
Predicted Functional Partners:
cbiA
Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
  
 0.999
cobT
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
  
 0.997
cobS
Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.994
AEB12724.1
Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: mrb:Mrub_0234 phosphoglycerate mutase; PFAM: Histidine phosphatase superfamily, clade-1; SMART: Histidine phosphatase superfamily, clade-1; SPTR: Phosphoglycerate mutase; IMG reference gene:2504661609; PFAM: Phosphoglycerate mutase family.
 
  
 0.956
AEB12502.1
ATP/cobalamin adenosyltransferase; COGs: COG2096 conserved hypothetical protein; InterPro IPR002779:IPR017858; KEGG: ttj:TTHA1926 ATP:cob(I)alamin adenosyltransferase; PFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, EutT/PduO type; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: Hypothetical conserved protein; TIGRFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, PduO-type, N-terminal; IMG reference gene:2504661377; PFAM: Cobalamin adenosyltransferase; TIGRFAM: ATP:cob(I)alamin adenosyltransferase.
  
 
 0.953
AEB12727.1
Iron-chelate-transporting ATPase; COGs: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components; InterPro IPR003593:IPR003439; KEGG: opr:Ocepr_0395 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Iron-chelate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Iron ABC transporter, ATP-binding protein; IMG reference gene:2504661612; PFAM: ABC transporter.
 
  
 0.939
hisC
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HAMAP: Histidinol-phosphate aminotransferase; InterPro IPR005861:IPR004839; KEGG: opr:Ocepr_0578 histidinol phosphate aminotransferase apoenzyme; PFAM: Aminotransferase, class I/classII; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase; IMG reference gene:2504660234; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotr [...]
 
  
 0.909
AEB12728.1
ABC-type transporter, integral membrane subunit; COGs: COG0609 ABC-type Fe3+-siderophore transport system permease component; InterPro IPR000522; KEGG: opr:Ocepr_0394 transport system permease protein; PFAM: ABC transporter permease protein; SPTR: Transport system permease protein; IMG reference gene:2504661613; PFAM: FecCD transport family; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
  
  
 0.854
AEB11171.1
Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: tth:TTC1956 phosphoglycerate mutase/fructose-2,6-bisphosphatase; PFAM: Histidine phosphatase superfamily, clade-1; SMART: Histidine phosphatase superfamily, clade-1; SPTR: Phosphoglycerate mutase/fructose-2,6-bisphosphatase; IMG reference gene:2504659997; PFAM: Phosphoglycerate mutase family.
 
  
 0.813
AEB12729.1
COGs: COG0614 ABC-type Fe3+-hydroxamate transport system periplasmic component; InterPro IPR002491; KEGG: opr:Ocepr_0393 periplasmic binding protein; PFAM: Periplasmic binding protein; SPTR: Iron ABC transporter, substrate-binding protein; IMG reference gene:2504661614; PFAM: Periplasmic binding protein.
  
  
 0.811
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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