STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AEB12743.1Mercuric reductase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR021179:IPR013027:IPR004099; KEGG: msv:Mesil_1148 mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Mercury(II) reductase; SPTR: Mercuric reductase; TIGRFAM: Mercury reductase, MerA; IMG reference gene:2504661630; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: mercuric reductase. (456 aa)    
Predicted Functional Partners:
AEB11458.1
Dihydrolipoyllysine-residue acetyltransferase; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: msv:Mesil_1134 catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: Catalytic domain of components of various dehydrogenase complexes; IMG reference gene:2504660296; PFAM: 2-oxoacid dehydrogenases acyltransferase (c [...]
 0.851
AEB11368.1
Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.848
AEB12749.1
Alkylmercury lyase; InterPro IPR004927; KEGG: xau:Xaut_0797 mercuric reductase; PFAM: Alkylmercury lyase; SPTR: Mercuric reductase; IMG reference gene:2504661636; PFAM: Alkylmercury lyase.
    
  0.825
AEB12587.1
2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.811
AEB11459.1
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: opr:Ocepr_1751 transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); SMART: Transketolase-like, pyrimidine-binding domain; SPTR: Transketolase central region; IMG reference gene:2504660297; PFAM: Transketolase, C-terminal domain; [...]
 
 0.805
AEB11975.1
COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: msv:Mesil_1851 transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: Pyruvate dehydrogenase (acetyl-transferring); SMART: Transketolase-like, pyrimidine-binding domain; SPTR: Transketolase central region; IMG reference gene:2504660829; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
 
 0.805
AEB12918.1
Redoxin domain protein; COGs: COG0526 Thiol-disulfide isomerase and thioredoxins; InterPro IPR013740; KEGG: ttj:TTHA0840 thiol:disulfide interchange protein; PFAM: Redoxin; SPTR: Thiol:disulfide interchange protein tlpA; IMG reference gene:2504661818; PFAM: Prolipoprotein diacylglyceryl transferase; Redoxin.
   
 0.797
AEB12742.1
Heavy metal transport/detoxification protein; COGs: COG2608 Copper chaperone; InterPro IPR006121; KEGG: hth:HTH_1325 mercuric reductase; PFAM: Heavy metal transport/detoxification protein; SPTR: Mercuric reductase; IMG reference gene:2504661629; PFAM: Heavy-metal-associated domain.
     
 0.786
AEB10900.1
E3 binding domain protein; InterPro IPR004167; KEGG: opr:Ocepr_0329 E3 binding domain protein; PFAM: E3 binding; SPTR: E3 binding domain protein; IMG reference gene:2504659706; PFAM: e3 binding domain.
  
 0.774
AEB12744.1
KEGG: msv:Mesil_1147 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504661631.
       0.773
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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