STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB12836.1Twitching motility protein; COGs: COG2805 Tfp pilus assembly protein pilus retraction ATPase PilT; InterPro IPR003593:IPR006321:IPR001482; KEGG: opr:Ocepr_0127 pilus retraction atpase PilT; PFAM: Type II secretion system protein E; SMART: ATPase, AAA+ type, core; SPTR: Twitching motility protein; TIGRFAM: Pilus retraction protein PilT; IMG reference gene:2504661731; PFAM: Type II/IV secretion system protein; TIGRFAM: pilus retraction protein PilT. (371 aa)    
Predicted Functional Partners:
AEB12837.1
COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR007831:IPR001482; KEGG: opr:Ocepr_0126 type II secretion system protein E; PFAM: Type II secretion system protein E; General secretory system II, protein E, N-terminal; SPTR: Type II secretion system protein E; IMG reference gene:2504661732; PFAM: Type II/IV secretion system protein; GSPII_E N-terminal domain.
 
  
0.866
AEB12844.1
Prepilin peptidase; COGs: COG1989 Type II secretory pathway prepilin signal peptidase PulO and related peptidase; InterPro IPR010627:IPR000045; KEGG: opr:Ocepr_0525 prepilin peptidase; PFAM: Peptidase A24A, N-terminal; Peptidase A24A, prepilin type IV; PRIAM: Prepilin peptidase; SPTR: Peptidase A24A domain protein; IMG reference gene:2504661739; PFAM: Bacterial Peptidase A24 N-terminal domain; Type IV leader peptidase family.
 
   
 0.806
AEB10910.1
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR018076; KEGG: mrb:Mrub_1042 type II secretion system protein; PFAM: Type II secretion system F domain; SPTR: General secretion pathway protein F; IMG reference gene:2504659717; PFAM: Bacterial type II secretion system protein F domain.
  
 0.803
AEB11710.1
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR018076; KEGG: opr:Ocepr_0813 type II secretion system f domain; PFAM: Type II secretion system F domain; SPTR: Type II secretion system protein; IMG reference gene:2504660555; PFAM: Bacterial type II secretion system protein F domain.
  
 0.803
AEB12269.1
COGs: COG4972 Tfp pilus assembly protein ATPase PilM; InterPro IPR005883; KEGG: opr:Ocepr_1388 type IV pilus assembly protein PilM; SPTR: Type IV pilus assembly protein PilM; TIGRFAM: Type IV pilus assembly protein PilM; IMG reference gene:2504661140; PFAM: Competence protein A; Cell division protein FtsA; TIGRFAM: type IV pilus assembly protein PilM.
 
   
 0.787
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
       0.762
AEB12838.1
HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; COGs: COG2179 hydrolase of the HAD superfamily; InterPro IPR010021:IPR006549:IPR005834; KEGG: mrb:Mrub_0948 HAD superfamily (subfamily IIIA) phosphatase TIGR01668; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: HAD superfamily (Subfamily IIIA) phosphatase, TIGR01668; TIGRFAM: HAD-superfamily phosphatase, subfamily IIIA; HAD-superfamily hydrolase, subfamily IIIA; IMG reference gene:2504661733; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IIIA; HAD superfamily (subfamily IIIA) phospha [...]
       0.592
AEB12839.1
Multi-copper polyphenol oxidoreductase, laccase; COGs: COG1496 conserved hypothetical protein; InterPro IPR003730; KEGG: msv:Mesil_0596 protein of unknown function DUF152; PFAM: Multi-copper polyphenol oxidoreductase, laccase; SPTR: Putative uncharacterized protein; TIGRFAM: Multi-copper polyphenol oxidoreductase, laccase; IMG reference gene:2504661734; PFAM: Multi-copper polyphenol oxidoreductase laccase; TIGRFAM: uncharacterized protein, YfiH family; Belongs to the multicopper oxidase YfiH/RL5 family.
       0.572
AEB12027.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR013655:IPR013767:IPR003018:IPR000160:IPR 001633:IPR000014:IPR001610; KEGG: aae:aq_1442 hypothetical protein; PFAM: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; GAF; PAS fold-3; PAS fold; SMART: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; GAF; PAS; PAC motif; SPTR: Putative uncharacterized protein; TIGRFAM: PAS; Diguanylate cyclase, predicted; IMG ref [...]
 
   
 0.544
AEB12966.1
DNA internalization-related competence protein ComEC/Rec2; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004477:IPR001279:IPR004797; KEGG: msv:Mesil_3192 DNA internalization-related competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; Beta-lactamase-like; SMART: Beta-lactamase-like; SPTR: DNA internalization-related competence protein ComEC/Rec2; TIGRFAM: Competence protein ComEC/Rec2; ComEC/Rec2-related protein; IMG reference gene:2504661868; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA i [...]
     
 0.483
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.