| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEJ60289.1 | AEJ60294.1 | Spith_0002 | Spith_0007 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.629 |
| AEJ60289.1 | AEJ60296.1 | Spith_0002 | Spith_0009 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Single-stranded nucleic acid binding R3H domain-containing protein; PFAM: R3H domain; COGs: COG1847 RNA-binding protein; InterPro IPR001374; KEGG: sta:STHERM_c00090 hypothetical protein; PFAM: Single-stranded nucleic acid binding R3H; SMART: Single-stranded nucleic acid binding R3H; SPTR: Single-stranded nucleic acid binding R3H domain-containing protein. | 0.651 |
| AEJ60289.1 | gcvH | Spith_0002 | Spith_0010 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.501 |
| AEJ60289.1 | rnpA | Spith_0002 | Spith_0006 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.831 |
| AEJ60289.1 | rplB | Spith_0002 | Spith_0521 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.404 |
| AEJ60289.1 | rpmH | Spith_0002 | Spith_0005 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: Ribosomal protein L34; TIGRFAM: ribosomal protein L34, bacterial type; HAMAP: 50S ribosomal protein L34; InterPro IPR000271; KEGG: sta:STHERM_c00060 50S ribosomal protein L34; PFAM: Ribosomal protein L34; SPTR: 50S ribosomal protein L34; TIGRFAM: Ribosomal protein L34. | 0.741 |
| AEJ60289.1 | rsmG | Spith_0002 | Spith_0277 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribosomal RNA small subunit methyltransferase G; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. | 0.425 |
| AEJ60289.1 | yidC | Spith_0002 | Spith_0008 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Membrane protein oxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.820 |
| AEJ60294.1 | AEJ60289.1 | Spith_0007 | Spith_0002 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.629 |
| AEJ60294.1 | AEJ60296.1 | Spith_0007 | Spith_0009 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Single-stranded nucleic acid binding R3H domain-containing protein; PFAM: R3H domain; COGs: COG1847 RNA-binding protein; InterPro IPR001374; KEGG: sta:STHERM_c00090 hypothetical protein; PFAM: Single-stranded nucleic acid binding R3H; SMART: Single-stranded nucleic acid binding R3H; SPTR: Single-stranded nucleic acid binding R3H domain-containing protein. | 0.902 |
| AEJ60294.1 | gcvH | Spith_0007 | Spith_0010 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.694 |
| AEJ60294.1 | rho | Spith_0007 | Spith_2039 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.737 |
| AEJ60294.1 | rnpA | Spith_0007 | Spith_0006 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.982 |
| AEJ60294.1 | rplB | Spith_0007 | Spith_0521 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.641 |
| AEJ60294.1 | rpmH | Spith_0007 | Spith_0005 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | PFAM: Ribosomal protein L34; TIGRFAM: ribosomal protein L34, bacterial type; HAMAP: 50S ribosomal protein L34; InterPro IPR000271; KEGG: sta:STHERM_c00060 50S ribosomal protein L34; PFAM: Ribosomal protein L34; SPTR: 50S ribosomal protein L34; TIGRFAM: Ribosomal protein L34. | 0.874 |
| AEJ60294.1 | yidC | Spith_0007 | Spith_0008 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Membrane protein oxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.954 |
| AEJ60296.1 | AEJ60289.1 | Spith_0009 | Spith_0002 | Single-stranded nucleic acid binding R3H domain-containing protein; PFAM: R3H domain; COGs: COG1847 RNA-binding protein; InterPro IPR001374; KEGG: sta:STHERM_c00090 hypothetical protein; PFAM: Single-stranded nucleic acid binding R3H; SMART: Single-stranded nucleic acid binding R3H; SPTR: Single-stranded nucleic acid binding R3H domain-containing protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.651 |
| AEJ60296.1 | AEJ60294.1 | Spith_0009 | Spith_0007 | Single-stranded nucleic acid binding R3H domain-containing protein; PFAM: R3H domain; COGs: COG1847 RNA-binding protein; InterPro IPR001374; KEGG: sta:STHERM_c00090 hypothetical protein; PFAM: Single-stranded nucleic acid binding R3H; SMART: Single-stranded nucleic acid binding R3H; SPTR: Single-stranded nucleic acid binding R3H domain-containing protein. | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.902 |
| AEJ60296.1 | AEJ61352.1 | Spith_0009 | Spith_1080 | Single-stranded nucleic acid binding R3H domain-containing protein; PFAM: R3H domain; COGs: COG1847 RNA-binding protein; InterPro IPR001374; KEGG: sta:STHERM_c00090 hypothetical protein; PFAM: Single-stranded nucleic acid binding R3H; SMART: Single-stranded nucleic acid binding R3H; SPTR: Single-stranded nucleic acid binding R3H domain-containing protein. | UPF0109 protein; PFAM: KH domain; COGs: COG1837 RNA-binding protein (contains KH domain); HAMAP: Uncharacterised protein family UPF0109, bacterial; InterPro IPR018111:IPR020627; KEGG: sta:STHERM_c10540 nucleic acid binding protein, containing KH domain; SPTR: Nucleic acid binding protein, containing KH domain; Belongs to the UPF0109 family. | 0.963 |
| AEJ60296.1 | gcvH | Spith_0009 | Spith_0010 | Single-stranded nucleic acid binding R3H domain-containing protein; PFAM: R3H domain; COGs: COG1847 RNA-binding protein; InterPro IPR001374; KEGG: sta:STHERM_c00090 hypothetical protein; PFAM: Single-stranded nucleic acid binding R3H; SMART: Single-stranded nucleic acid binding R3H; SPTR: Single-stranded nucleic acid binding R3H domain-containing protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.749 |
