STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60357.1PFAM: UvrD/REP helicase; COGs: COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); InterPro IPR000212; KEGG: sta:STHERM_c00830 hypothetical protein; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase. (1149 aa)    
Predicted Functional Partners:
AEJ60356.1
KEGG: sta:STHERM_c00820 hypothetical protein; SPTR: Putative uncharacterized protein.
  
 
 0.992
ligA
DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
 
 
 0.530
AEJ60355.1
KEGG: sta:STHERM_c00810 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.508
AEJ61625.1
PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (polc); COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR003141:IPR004013:IPR011708:IPR004365:IPR 004805; KEGG: sta:STHERM_c08090 DNA polymerase III subunit alpha; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit.
 
  
 0.503
AEJ60947.1
PFAM: DHH family; DHHA1 domain; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterPro IPR004610:IPR001667:IPR003156; KEGG: sta:STHERM_c06530 single-stranded-DNA-specific exonuclease; PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; SPTR: Single-stranded-DNA-specific exonuclease RecJ; TIGRFAM: Bacterial RecJ exonuclease.
 
   
 0.477
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.477
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.459
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.453
AEJ60353.1
KEGG: sta:STHERM_c00790 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.448
AEJ60354.1
KEGG: sta:STHERM_c00800 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.448
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.