Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60359.1Alpha-2-macroglobulin domain protein; PFAM: Alpha-macro-globulin thiol-ester bond-forming region; MG2 domain; Alpha-2-macroglobulin family N-terminal region; Alpha-2-macroglobulin MG1 domain; COGs: COG2373 Large extracellular alpha-helical protein; InterPro IPR002890:IPR011625; KEGG: sta:STHERM_c00850 inner membrane lipoprotein; PFAM: Alpha-2-macroglobulin, N-terminal; Alpha-2-macroglobulin, N-terminal 2; SPTR: Alpha-2-macroglobulin domain protein. (1839 aa)    
Predicted Functional Partners:
AEJ60360.1
PFAM: Penicillin-Binding Protein C-terminus Family; Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: penicillin-binding protein 1C; COGs: COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC; InterPro IPR001264:IPR001460:IPR009647:IPR011815; KEGG: sta:STHERM_c00860 hypothetical protein; PFAM: Glycosyl transferase, family 51; Penicillin-binding protein, transpeptidase; Penicillin-binding, C-terminal; SPTR: Penicillin-binding protein 1C; TIGRFAM: Penicillin-binding protein 1C.
 
   
 0.960
AEJ60361.1
Glycosidase related protein; PFAM: Domain of unknown function (DUF377); COGs: COG2152 glycosylase; InterPro IPR007184; KEGG: sta:STHERM_c00870 glycosylase; PFAM: Glycosidase, PH1107-related; SPTR: Glycosidase related protein.
       0.548
fabH
3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
       0.527
AEJ60362.1
PFAM: Bacterial extracellular solute-binding protein; COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: sta:STHERM_c00880 hypothetical protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1.
       0.475
AEJ62011.1
PFAM: Alginate lyase; InterPro IPR014895; KEGG: cpy:Cphy_0492 alginate lyase 2; PFAM: Alginate lyase 2; SPTR: Alginate lyase 2.
  
     0.459
nrdR
Transcriptional repressor nrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
    
   0.417
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.416
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.