Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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AEJ60360.1PFAM: Penicillin-Binding Protein C-terminus Family; Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: penicillin-binding protein 1C; COGs: COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC; InterPro IPR001264:IPR001460:IPR009647:IPR011815; KEGG: sta:STHERM_c00860 hypothetical protein; PFAM: Glycosyl transferase, family 51; Penicillin-binding protein, transpeptidase; Penicillin-binding, C-terminal; SPTR: Penicillin-binding protein 1C; TIGRFAM: Penicillin-binding protein 1C. (859 aa)    
Predicted Functional Partners:
AEJ60359.1
Alpha-2-macroglobulin domain protein; PFAM: Alpha-macro-globulin thiol-ester bond-forming region; MG2 domain; Alpha-2-macroglobulin family N-terminal region; Alpha-2-macroglobulin MG1 domain; COGs: COG2373 Large extracellular alpha-helical protein; InterPro IPR002890:IPR011625; KEGG: sta:STHERM_c00850 inner membrane lipoprotein; PFAM: Alpha-2-macroglobulin, N-terminal; Alpha-2-macroglobulin, N-terminal 2; SPTR: Alpha-2-macroglobulin domain protein.
 
   
 0.960
AEJ61705.1
Penicillin-binding protein, 1A family; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: penicillin-binding protein, 1A family; COGs: COG5009 Membrane carboxypeptidase/penicillin-binding protein; InterPro IPR001264:IPR001460:IPR011816; KEGG: sta:STHERM_c07150 penicillin-binding protein; PFAM: Glycosyl transferase, family 51; Penicillin-binding protein, transpeptidase; SPTR: Penicillin-binding protein, 1A family; TIGRFAM: Penicillin-binding protein 1A.
  
  
0.926
AEJ61388.1
Penicillin-binding protein 2; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain; TIGRFAM: penicillin-binding protein 2; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR005311:IPR001460:IPR017790; KEGG: sta:STHERM_c10880 penicillin-binding protein; PFAM: Penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; SPTR: Penicillin-binding protein 2; TIGRFAM: Penicillin-binding protein 2.
  
  
 0.924
AEJ61683.1
PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain; PASTA domain; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR005543:IPR005311:IPR001460; KEGG: sta:STHERM_c07450 penicillin-binding protein; PFAM: Penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; PASTA; SMART: PASTA; SPTR: Peptidoglycan glycosyltransferase.
     
 0.908
AEJ62110.1
PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain; COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterPro IPR001967:IPR012907; KEGG: sta:STHERM_c17820 D-alanyl-D-alanine carboxypeptidase A; PFAM: Peptidase S11, D-alanyl-D-alanine carboxypeptidase A; Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal; SPTR: Serine-type D-Ala-D-Ala carboxypeptidase.
     
 0.902
AEJ61960.1
Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin; PFAM: D-alanyl-D-alanine carboxypeptidase; COGs: COG1876 D-alanyl-D-alanine carboxypeptidase; InterPro IPR003709; KEGG: sta:STHERM_c16390 hypothetical protein; PFAM: Peptidase M15B/M15C, D,D-carboxypeptidase VanY/endolysins; SPTR: Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin.
     
  0.900
AEJ60361.1
Glycosidase related protein; PFAM: Domain of unknown function (DUF377); COGs: COG2152 glycosylase; InterPro IPR007184; KEGG: sta:STHERM_c00870 glycosylase; PFAM: Glycosidase, PH1107-related; SPTR: Glycosidase related protein.
       0.548
fabH
3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
       0.527
AEJ60362.1
PFAM: Bacterial extracellular solute-binding protein; COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: sta:STHERM_c00880 hypothetical protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1.
       0.475
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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