STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60390.1PFAM: Major Facilitator Superfamily; PBS lyase HEAT-like repeat; HEAT repeat; COGs: COG1413 FOG: HEAT repeat; InterPro IPR011701:IPR004155; KEGG: sta:STHERM_c01150 major facilitator superfamily MFS_1; PFAM: Major facilitator superfamily MFS-1; PBS lyase HEAT-like repeat; SMART: PBS lyase HEAT-like repeat; SPTR: Major facilitator superfamily MFS_1. (766 aa)    
Predicted Functional Partners:
AEJ60389.1
PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015794:IPR001697; KEGG: sta:STHERM_c01140 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase.
  
  
 0.635
AEJ61409.1
PBS lyase HEAT domain protein repeat-containing protein; PFAM: PBS lyase HEAT-like repeat; HEAT repeat; COGs: COG1413 FOG: HEAT repeat; InterPro IPR004155; KEGG: sta:STHERM_c11080 PBS lyase heat-like repeat domain-containing protein; PFAM: PBS lyase HEAT-like repeat; SMART: PBS lyase HEAT-like repeat; SPTR: PBS lyase HEAT domain protein repeat-containing protein.
 
     0.622
AEJ60391.1
CheA signal transduction histidine kinase; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterPro IPR008207:IPR004105:IPR003594:IPR002545; KEGG: sta:STHERM_c01160 hypothetical protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, phosphotransfer (Hpt) region; Signal transduction histidine kinase, subgroup, homodimeric; CheW-like protein; SMART: ATP-binding region, ATPase-like; Signal [...]
       0.517
AEJ60392.1
PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: sta:STHERM_c01170 hypothetical protein; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver protein.
       0.517
AEJ60393.1
PFAM: CheW-like domain; COGs: COG0835 Chemotaxis signal transduction protein; InterPro IPR002545; KEGG: sta:STHERM_c01180 hypothetical protein; PFAM: CheW-like protein; SMART: CheW-like protein; SPTR: CheW protein.
       0.487
AEJ60394.1
Hypothetical protein; PFAM: Methyl-accepting chemotaxis protein (MCP) signaling domain; KEGG: sta:STHERM_c01190 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.487
AEJ60395.1
MCP methyltransferase, CheR-type; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; InterPro IPR000780; KEGG: sta:STHERM_c01200 chemotaxis protein methyltransferase; PFAM: MCP methyltransferase, CheR-type; SMART: MCP methyltransferase, CheR-type; SPTR: MCP methyltransferase, CheR-type.
       0.487
cheD
CheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family.
       0.487
cheB
Response regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
       0.487
AEJ62526.1
PFAM: FecR protein; KEGG: sta:STHERM_c22260 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.487
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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