STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60413.1Phosphoesterase RecJ domain protein; PFAM: DHHA1 domain; DHH family; COGs: COG0618 Exopolyphosphatase-related protein; InterPro IPR001667; KEGG: sta:STHERM_c01380 DHH superfamily protein, subfamily 1; PFAM: Phosphoesterase, RecJ-like; SPTR: Phosphoesterase RecJ domain protein. (320 aa)    
Predicted Functional Partners:
AEJ60412.1
PFAM: Tetratricopeptide repeat; COGs: COG5010 Flp pilus assembly protein TadD contains TPR repeats; InterPro IPR001440:IPR019734; KEGG: sta:STHERM_c01370 lipoprotein; PFAM: Tetratricopeptide TPR-1; SPTR: Tetratricopeptide TPR_1 repeat-containing protein.
       0.787
AEJ60414.1
PFAM: TraB family; TIGRFAM: pheromone shutdown-related protein TraB; COGs: COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein); InterPro IPR002816:IPR005230; KEGG: sta:STHERM_c01390 TraB family protein; PFAM: Pheromone shutdown-related, TraB; SPTR: TraB family protein; TIGRFAM: Pheromone shutdown, TraB.
       0.787
AEJ60415.1
Protein of unknown function DUF218; PFAM: DUF218 domain; COGs: COG1434 conserved hypothetical protein; InterPro IPR003848; KEGG: sta:STHERM_c01400 transmembrane protein; PFAM: Protein of unknown function DUF218; SPTR: Putative uncharacterized protein.
       0.777
rbfA
Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
  
    0.686
AEJ60416.1
Integral membrane sensor hybrid histidine kinase; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594:IPR001789; KEGG: sta:STHERM_c01410 transcriptional regulatory protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; Signal transduction response regulator, receiver region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine [...]
       0.674
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
       0.654
AEJ60411.1
KEGG: sta:STHERM_c01360 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.548
infB
Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
  
    0.419
AEJ60467.1
Radical SAM domain protein; COGs: COG1533 DNA repair photolyase; InterPro IPR007197; KEGG: sta:STHERM_c01960 photolyase-like protein; PFAM: Radical SAM; SPTR: Radical SAM domain protein.
  
     0.402
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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