STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60437.1PFAM: Iron-containing alcohol dehydrogenase; COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670; KEGG: sta:STHERM_c01620 hypothetical protein; PFAM: Alcohol dehydrogenase, iron-type; SPTR: Iron-containing alcohol dehydrogenase. (379 aa)    
Predicted Functional Partners:
AEJ60438.1
tRNA/rRNA methyltransferase (SpoU); PFAM: SpoU rRNA Methylase family; COGs: COG0566 rRNA methylase; InterPro IPR001537; KEGG: sta:STHERM_c01630 RNA methyltransferase, TrmH family; PFAM: tRNA/rRNA methyltransferase, SpoU; SPTR: tRNA/rRNA methyltransferase (SpoU).
       0.811
AEJ60436.1
PFAM: Anti-sigma-28 factor, FlgM; InterPro IPR007412; KEGG: sta:STHERM_c01610 hypothetical protein; PFAM: Anti-sigma-28 factor, FlgM; SPTR: Anti-sigma-28 factor FlgM family protein.
       0.746
AEJ62081.1
PFAM: Iron-containing alcohol dehydrogenase; COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670; KEGG: sta:STHERM_c17510 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type; SPTR: Iron-containing alcohol dehydrogenase.
  
     0.652
glgA
Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose.
   
  
 0.616
rsmI
Ribosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
       0.613
AEJ61982.1
PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: sta:STHERM_c16630 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin ox [...]
  
  
 0.568
AEJ61771.1
Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; 4Fe-4S binding domain; Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain; COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterPro IPR011538:IPR019554:IPR019575:IPR001450; KEGG: sta:STHERM_c13750 hypothetical protein; PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4 [...]
  
  
 0.467
AEJ61854.1
CoA-substrate-specific enzyme activase; PFAM: 2-hydroxyglutaryl-CoA dehydratase, D-component; BadF/BadG/BcrA/BcrD ATPase family; CoA enzyme activase uncharacterised domain (DUF2229); TIGRFAM: CoA-substrate-specific enzyme activase, putative; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR008275:IPR002731:IPR018709; KEGG: sta:STHERM_c15510 hypothetical protein; PFAM: Protein of unknown function DUF2229, CoA enzyme activase; ATPase, BadF/BadG/BcrA/BcrD type; SPTR: CoA-substrate-specific enzyme activase; TIGRFAM: CoA enzyme activase.
   
  
 0.442
AEJ61472.1
PFAM: Radical SAM superfamily; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR007197:IPR006638; KEGG: sta:STHERM_c11670 hypothetical protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
  
  
 0.438
AEJ61730.1
PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR007197:IPR012840; KEGG: sta:STHERM_c06800 hypothetical protein; PFAM: Radical SAM; SPTR: Anaerobic ribonucleoside-triphosphate reductase activating protein; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic-like.
  
  
 0.438
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.