STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panB3-methyl-2-oxobutanoatehydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa)    
Predicted Functional Partners:
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
  
 0.976
AEJ60449.1
PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544:IPR005786; KEGG: sta:STHERM_c01780 branched-chain-amino-acid aminotransferase; PFAM: Aminotransferase, class IV; SPTR: Branched-chain-amino-acid aminotransferase; TIGRFAM: Branched-chain amino acid aminotransferase II; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
 0.920
ilvD
PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: sta:STHERM_c14560 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
     
 0.918
AEJ61335.1
Nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR002638:IPR004393; KEGG: sta:STHERM_c10350 hypothetical protein; PFAM: Quinolinate phosphoribosyl transferase; SPTR: Nicotinate-nucleotide pyrophosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family.
     0.752
AEJ60483.1
PFAM: Flavoprotein; COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR003382; KEGG: sta:STHERM_c02120 pantothenate metabolism flavoprotein; PFAM: Flavoprotein; SPTR: Phosphopantothenoylcysteine decarboxylase.
 
   
 0.741
AEJ60484.1
PFAM: DNA / pantothenate metabolism flavoprotein; COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR007085; KEGG: sta:STHERM_c02130 DNA / pantothenate metabolism flavoprotein; PFAM: DNA/pantothenate metabolism flavoprotein, C-terminal; SPTR: DNA/pantothenate metabolism flavoprotein domain protein.
     
 0.662
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.527
AEJ60479.1
Protein of unknown function DUF214; PFAM: Predicted permease; COGs: COG4591 ABC-type transport system involved in lipoprotein release permease component; InterPro IPR003838; KEGG: sta:STHERM_c02080 permease, involved in lipoprotein release; PFAM: Protein of unknown function DUF214, permase predicted; SPTR: Putative uncharacterized protein.
       0.506
AEJ60480.1
PFAM: ABC transporter; COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: sta:STHERM_c02090 ATP-binding/permease MacB; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein.
       0.506
AEJ60481.1
PFAM: Bacterial regulatory proteins, tetR family; COGs: COG1309 Transcriptional regulator; InterPro IPR001647; KEGG: sta:STHERM_c02100 transcriptional activator; PFAM: Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal; SPTR: Transcriptional regulator, TetR family.
       0.506
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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