STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60488.1PFAM: GHMP kinases N terminal domain; COGs: COG1829 kinase (sugar kinase superfamily); InterPro IPR006204; KEGG: sta:STHERM_c02170 kinase; PFAM: GHMP kinase; SPTR: GHMP kinase. (301 aa)    
Predicted Functional Partners:
AEJ60487.1
PFAM: Protein of unknown function DUF137; COGs: COG1701 conserved hypothetical protein; InterPro IPR002855; KEGG: sta:STHERM_c02160 hypothetical protein; PFAM: Protein of unknown function DUF137; SPTR: Pantothenate synthetase.
 
  
 0.995
AEJ60917.1
Malic protein NAD-binding protein; PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302; KEGG: sta:STHERM_c06230 hypothetical protein; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; SPTR: Malic protein NAD-binding.
  
    0.757
AEJ60486.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
       0.741
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.622
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
    0.615
AEJ62001.1
PFAM: ATPase family associated with various cellular activities (AAA); COGs: COG0714 MoxR-like ATPase; InterPro IPR003593:IPR011703; KEGG: sta:STHERM_c16810 hypothetical protein; PFAM: ATPase associated with various cellular activities, AAA-3; SMART: ATPase, AAA+ type, core; SPTR: ATPase associated with various cellular activities AAA_3.
   
    0.546
AEJ60489.1
PFAM: Malate/L-lactate dehydrogenase; COGs: COG2055 Malate/L-lactate dehydrogenase; InterPro IPR003767; KEGG: sta:STHERM_c02180 ureidoglycolate dehydrogenase; PFAM: Malate/L-lactate dehydrogenase; SPTR: Malate/L-lactate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family.
       0.515
cmk-2
PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase, putative; COGs: COG1102 Cytidylate kinase; HAMAP: Cytidylate kinase; InterPro IPR000623:IPR011892; KEGG: sta:STHERM_c12230 cytidylate kinase; PFAM: Shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: Cytidylate kinase, putative.
  
     0.483
AEJ61059.1
PFAM: ABC transporter; COGs: COG1122 ABC-type cobalt transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: sta:STHERM_c14480 membrane associated ATPase; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein.
  
     0.461
pheT
Phenylalanyl-tRNA synthetase beta chain; PFAM: tRNA synthetases class II core domain (F); tRNA synthetase B5 domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; HAMAP: Phenylalanyl-tRNA synthetase beta chain; InterPro IPR004531:IPR005147; KEGG: sta:STHERM_c21760 phenylalanyl-tRNA synthetase subunit beta; PFAM: tRNA synthetase, B5; SPTR: Phenylalanyl-tRNA synthetase beta chain; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic.
  
    0.456
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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