Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ60495.1PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase; COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: sta:STHERM_c02250 5-formyltetrahydrofolatecyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase. (184 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 
 0.926
folD
Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.921
AEJ60496.1
PFAM: Endoribonuclease L-PSP; TIGRFAM: endoribonuclease L-PSP, putative; COGs: COG0251 Putative translation initiation inhibitor yjgF family; InterPro IPR006175:IPR006056; KEGG: sta:STHERM_c02260 endoribonuklease; PFAM: Endoribonuclease L-PSP; SPTR: Putative endoribonuklease; TIGRFAM: YjgF-like protein.
     
 0.783
AEJ60497.1
Protein of unknown function DUF1121; PFAM: Uncharacterised ACR, YkgG family COG1556; InterPro IPR009501; KEGG: sta:STHERM_c02270 hypothetical protein; PFAM: Protein of unknown function DUF1121; SPTR: Putative uncharacterized protein.
     
 0.724
AEJ60494.1
KEGG: sta:STHERM_c02240 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.686
AEJ60493.1
PFAM: Major Facilitator Superfamily; InterPro IPR011701; KEGG: sta:STHERM_c02230 major facilitator superfamily MFS-1; PFAM: Major facilitator superfamily MFS-1; SPTR: Major facilitator superfamily MFS_1.
       0.585
AEJ60498.1
Sulfate transporter/antisigma-factor antagonist STAS; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; InterPro IPR002645; KEGG: sta:STHERM_c02280 anti-anti sigma factor; PFAM: Sulphate transporter/antisigma-factor antagonist STAS; SPTR: Sulfate transporter/antisigma-factor antagonist STAS.
       0.512
AEJ62182.1
PFAM: Rhomboid family; COGs: COG0705 membrane protein; InterPro IPR002610; KEGG: sta:STHERM_c18790 rhomboid family protein; PFAM: Peptidase S54, rhomboid; SPTR: Rhomboid family protein.
  
  
 0.452
AEJ62231.1
PFAM: Rhomboid family; InterPro IPR002610; KEGG: sta:STHERM_c19270 rhomboid-like protein; PFAM: Peptidase S54, rhomboid; SPTR: Rhomboid family protein.
  
  
 0.452
AEJ62474.1
PFAM: Rhomboid family; COGs: COG0705 membrane protein; InterPro IPR002610; KEGG: sta:STHERM_c21730 rhomboid family protein; PFAM: Peptidase S54, rhomboid; SPTR: Rhomboid family protein.
  
  
 0.452
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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