Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ60497.1Protein of unknown function DUF1121; PFAM: Uncharacterised ACR, YkgG family COG1556; InterPro IPR009501; KEGG: sta:STHERM_c02270 hypothetical protein; PFAM: Protein of unknown function DUF1121; SPTR: Putative uncharacterized protein. (214 aa)    
Predicted Functional Partners:
AEJ60495.1
PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase; COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: sta:STHERM_c02250 5-formyltetrahydrofolatecyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase.
     
 0.724
AEJ60496.1
PFAM: Endoribonuclease L-PSP; TIGRFAM: endoribonuclease L-PSP, putative; COGs: COG0251 Putative translation initiation inhibitor yjgF family; InterPro IPR006175:IPR006056; KEGG: sta:STHERM_c02260 endoribonuklease; PFAM: Endoribonuclease L-PSP; SPTR: Putative endoribonuklease; TIGRFAM: YjgF-like protein.
       0.724
AEJ62074.1
HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; 2-phosphoglycolate phosphatase, prokaryotic; COGs: COG0546 phosphatase; InterPro IPR006402:IPR006439:IPR005834; KEGG: sta:STHERM_c17440 hydrolase; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: HAD-superfamily hydrolase, subfamily IA, variant 3; TIGRFAM: HAD-superfamily hydrolase, subf [...]
 
      0.636
AEJ60494.1
KEGG: sta:STHERM_c02240 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.622
AEJ60498.1
Sulfate transporter/antisigma-factor antagonist STAS; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; InterPro IPR002645; KEGG: sta:STHERM_c02280 anti-anti sigma factor; PFAM: Sulphate transporter/antisigma-factor antagonist STAS; SPTR: Sulfate transporter/antisigma-factor antagonist STAS.
       0.548
AEJ60493.1
PFAM: Major Facilitator Superfamily; InterPro IPR011701; KEGG: sta:STHERM_c02230 major facilitator superfamily MFS-1; PFAM: Major facilitator superfamily MFS-1; SPTR: Major facilitator superfamily MFS_1.
  
    0.546
AEJ60346.1
PFAM: Aldo/keto reductase family; COGs: COG1453 oxidoreductase of the aldo/keto reductase family; InterPro IPR001395; KEGG: sta:STHERM_c00730 hypothetical protein; PFAM: Aldo/keto reductase; SPTR: Aldo/keto reductase.
 
   0.541
AEJ62321.1
PFAM: 4Fe-4S binding domain; InterPro IPR001450; KEGG: sta:STHERM_c20140 hypothetical protein; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Iron-sulfur cluster-binding protein.
  
 
   0.431
AEJ61390.1
Radical SAM domain protein; PFAM: Uncharacterized protein conserved in bacteria (DUF2344); Radical SAM superfamily; TIGRFAM: radical SAM-linked protein; COGs: COG1032 Fe-S oxidoreductase; InterPro IPR007197:IPR018768:IPR006638; KEGG: sta:STHERM_c10900 hypothetical protein; PFAM: Radical SAM; Protein of unknown function DUF2344; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
 
   
 0.411
AEJ60502.1
Auxin Efflux Carrier; PFAM: Membrane transport protein; COGs: COG0679 permease; InterPro IPR004776; KEGG: sta:STHERM_c02320 efflux carrier; PFAM: Auxin efflux carrier; SPTR: Auxin Efflux Carrier.
 
     0.410
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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