STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60535.1Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; InterPro IPR004843; KEGG: sta:STHERM_c02680 hydrolase; PFAM: Metallophosphoesterase; SPTR: Metallophosphoesterase. (291 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.904
pfkA-2
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
       0.762
AEJ60849.1
Helicase c2; PFAM: Protein of unknown function (DUF2466); DEAD/DEAH box helicase; TIGRFAM: DnaQ family exonuclease/DinG family helicase, putative; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006555; KEGG: sta:STHERM_c05470 hypothetical protein; SMART: Helicase, ATP-dependent, c2 type; SPTR: Helicase c2.
   
 0.701
AEJ61247.1
PFAM: Ankyrin repeat; COGs: COG0666 FOG: Ankyrin repeat; InterPro IPR002110; KEGG: sta:STHERM_c09480 ankyrin repeat-containing protein; PFAM: Ankyrin repeat; SMART: Ankyrin repeat; SPTR: Ankyrin.
    
  0.682
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.596
AEJ60536.1
KEGG: sta:STHERM_c02690 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.588
AEJ60533.1
PFAM: Glycosyl hydrolase family 9; N-terminal ig-like domain of cellulase; InterPro IPR001701; KEGG: sta:STHERM_c02660 glycoside hydrolase, family 9; PFAM: Glycoside hydrolase, family 9; SPTR: Glycoside hydrolase family 9.
       0.570
AEJ62343.1
TIGRFAM: monofunctional chorismate mutase, eukaryotic type; InterPro IPR008238; KEGG: sta:STHERM_c20450 chorismate mutase; SPTR: Chorismate mutase; TIGRFAM: Chorismate mutase, AroQ class, eukaryotic type.
  
     0.478
AEJ61668.1
Flagellar hook-associated protein FlgK; PFAM: Flagellin hook IN motif; Domain of unknown function (DUF1078); TIGRFAM: flagellar hook-associated protein FlgK; COGs: COG1256 Flagellar hook-associated protein; InterPro IPR010810:IPR010930:IPR002371; KEGG: sta:STHERM_c07620 flagellar hook-associated protein; PFAM: Protein of unknown function DUF1078, C-terminal; Flagellin hook, IN motif; SPTR: Flagellar hook-associated protein FlgK; TIGRFAM: Flagellar hook-associated protein, FlgK.
    
   0.454
rpsO
Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
 
     0.450
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.