STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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Coexpression
Experiments
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Textmining
[Homology]
Score
AEJ60565.1Diguanylate cyclase/phosphodiesterase; PFAM: EAL domain; COGs: COG2200 FOG: EAL domain; InterPro IPR000160:IPR001633; KEGG: sta:STHERM_c02950 sensory box/GGDEF family protein; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase/phosphodiesterase. (478 aa)    
Predicted Functional Partners:
AEJ61090.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR013656:IPR003661:IPR003594:IPR 001789:IPR008207; KEGG: sta:STHERM_c14170 two-component system, sensor histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; Signal transduction response regulator, receiver region; Signal transducti [...]
  
 0.974
AEJ60715.1
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; Response regulator receiver domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000014:IPR000160:IPR001789:IPR001633:IPR 013767; KEGG: sta:STHERM_c04670 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Signal transduction response regulator, receiver region; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclas [...]
 
 
0.968
AEJ60351.1
Diguanylate cyclase; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160; KEGG: sta:STHERM_c00770 hypothetical protein; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted.
 
 0.948
AEJ60492.1
Multi-sensor hybrid histidine kinase; PFAM: 7TM diverse intracellular signalling; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; Hpt domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594:IPR001789:IPR008207; KEGG: sta:STHERM_c02220 histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, p [...]
  
 0.946
AEJ60305.1
Diguanylate cyclase; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160; KEGG: sta:STHERM_c00180 hypothetical protein; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Putative uncharacterized protein; TIGRFAM: Diguanylate cyclase, predicted.
  
 0.896
AEJ60614.1
Multi-sensor signal transduction histidine kinase; PFAM: Ammonium Transporter Family; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hpt domain; TIGRFAM: ammonium transporter; COGs: COG0004 Ammonia permease; InterPro IPR001905:IPR003594:IPR013767:IPR008207; KEGG: sta:STHERM_c03600 ammonia permease with sensory box/GGDEF domains; PFAM: Ammonium transporter; PAS fold; Signal transduction histidine kinase, phosphotransfer (Hpt) region; ATP-binding region, ATPase-like; SMART: ATP-binding region, ATPase-like; SPTR: Multi-sensor signal transduction histidine kinase; TIGRFAM: Ammoni [...]
 
  
 0.864
AEJ60622.1
Diguanylate cyclase with PAS/PAC sensor; PFAM: GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR000014:IPR013656; KEGG: sta:STHERM_c03690 GGDEF domain-containing protein; PFAM: Diguanylate cyclase, predicted; PAS fold-4; SMART: Diguanylate cyclase, predicted; PAS; SPTR: Diguanylate cyclase with PAS/PAC sensor; TIGRFAM: Diguanylate cyclase, predicted.
  
 0.831
AEJ62223.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; Cache domain; HAMP domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterProIPR013163:IPR003660:IPR013767:IPR000160:IPR 001633:IPR000014; KEGG: sta:STHERM_c19190 hypothetical protein; PFAM: Diguanylate cyclase, predicted; HAMP linker domain; Cache, type 2; PAS fold; Diguanylate phosphodiesterase, predicted; SMART: Diguanylate cyclase, predicted; HAMP linker domain; PAS; Diguanylate phosphodiesterase, predicted; SPTR: Diguanylate [...]
 
  
 0.826
AEJ60861.1
Diguanylate cyclase; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000160; KEGG: sta:STHERM_c05610 hypothetical protein; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted.
  
 0.819
AEJ61810.1
Diguanylate cyclase; PFAM: Cache domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000160; KEGG: sta:STHERM_c14110 hypothetical protein; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted.
  
 0.819
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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