STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (294 aa)    
Predicted Functional Partners:
lipB
Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.998
AEJ62524.1
PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: lipoyltransferase and lipoate-protein ligase; COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: sta:STHERM_c22240 lipoate-protein ligase A; PFAM: Biotin/lipoate A/B protein ligase; SPTR: Lipoate--protein ligase.
  
 
 0.931
AEJ60578.1
KEGG: sta:STHERM_c03090 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.546
AEJ60579.1
PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR006935:IPR001650:IPR014001; KEGG: sta:STHERM_c03100 DNA-helicase; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Type III restriction protein res subunit.
       0.546
AEJ60585.1
PFAM: 2Fe-2S iron-sulfur cluster binding domain; Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain; COGs: COG2871 Na+-transporting NADH:ubiquinone oxidoreductase subunit NqrF; InterPro IPR001041:IPR008333:IPR001433; KEGG: sta:STHERM_c03160 Na(+)-translocating NADH-quinone reductase subunit F; PFAM: Oxidoreductase FAD-binding region; Ferredoxin; Oxidoreductase FAD/NAD(P)-binding; SPTR: Oxidoreductase FAD-binding domain protein.
       0.533
AEJ62280.1
Transketolase domain-containing protein; PFAM: Dehydrogenase E1 component; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; Transketolase, C-terminal domain; Biotin-requiring enzyme; Transketolase, pyrimidine binding domain; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterProIPR001017:IPR005475:IPR005476:IPR000089:IPR 013751:IPR013747; KEGG: sta:STHERM_c19760 hypothetical protein; PFAM: Tr [...]
  
  
 0.533
AEJ60581.1
PFAM: NQR2, RnfD, RnfE family; TIGRFAM: electron transport complex, RnfABCDGE type, D subunit; COGs: COG4658 NADH:ubiquinone oxidoreductase subunit RnfD; InterPro IPR004338; KEGG: sta:STHERM_c03120 NADH:ubiquinone oxidoreductase, Na translocating, B subunit; PFAM: NADH-quinone reductase NQR2/RnfD; SPTR: NQR2 and RnfD family protein.
       0.496
rnfG
FMN-binding domain protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
       0.496
AEJ60583.1
PFAM: Rnf-Nqr subunit, membrane protein; TIGRFAM: NADH:ubiquinone oxidoreductase, Na(+)-translocating, D subunit; COGs: COG1347 Na+-transporting NADH:ubiquinone oxidoreductase subunit NqrD; InterPro IPR003667:IPR011292; KEGG: sta:STHERM_c03140 Na(+)-translocating NADH-quinone reductase subunit D; PFAM: Electron transport complex, Rnf/Nqr; SPTR: NADH:ubiquinone oxidoreductase, subunit D; TIGRFAM: NADH:ubiquinone oxidoreductase, Na(+)-translocating, D subunit; Belongs to the NqrDE/RnfAE family.
       0.496
rnfA
RnfA-Nqr electron transport subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
       0.496
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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