Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ60628.1PFAM: CBS domain; Sodium/hydrogen exchanger family; COGs: COG0475 Kef-type K+ transport systems membrane components; InterPro IPR000644:IPR006153; KEGG: sta:STHERM_c03750 sodium/hydrogen exchanger family protein; PFAM: Cation/H+ exchanger; Cystathionine beta-synthase, core; SPTR: Sodium/hydrogen exchanger. (557 aa)    
Predicted Functional Partners:
AEJ60627.1
Putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); InterPro IPR002178; KEGG: sta:STHERM_c03740 hypothetical protein; PFAM: Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2; SPTR: Putative PTS IIA-like nitrogen-regulatory protein PtsN.
       0.785
AEJ60626.1
Putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; TIGRFAM: DNA binding domain, excisionase family; COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); InterPro IPR010093:IPR002178; KEGG: sta:STHERM_c03730 hypothetical protein; PFAM: Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2; SPTR: Putative PTS IIA-like nitrogen-regulatory protein PtsN; TIGRFAM: Excisionase/Xis, DNA-binding.
       0.777
AEJ60629.1
KEGG: rmr:Rmar_2140 transposase-like protein; SPTR: Transposase-like protein.
       0.515
AEJ60630.1
Transposase IS3/IS911 family protein; PFAM: Integrase core domain; Transposase; InterPro IPR002514; KEGG: tye:THEYE_A0843 ISCc3, transposase OrfA; PFAM: Transposase IS3/IS911; SPTR: Transposase IS3/IS911 family protein; manually curated.
       0.490
AEJ60631.1
Hypothetical protein; KEGG: rmr:Rmar_2140 transposase-like protein; SPTR: Putative uncharacterized protein.
       0.490
AEJ60625.1
KEGG: sta:STHERM_c03720 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.485
AEJ61982.1
PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: sta:STHERM_c16630 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin ox [...]
     
 0.446
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
     0.442
AEJ61085.1
KEGG: sta:STHERM_c14220 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.414
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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