STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60650.1PFAM: Glycosyl hydrolases family 31; COGs: COG1501 Alpha-glucosidase family 31 of glycosyl hydrolase; InterPro IPR000322; KEGG: sta:STHERM_c03990 glycoside hydrolase, family 31; PFAM: Glycoside hydrolase, family 31; SPTR: Glycoside hydrolase family 31. (761 aa)    
Predicted Functional Partners:
AEJ60642.1
Glycoside hydrolase family 42 domain protein; PFAM: Beta-galactosidase trimerisation domain; Beta-galactosidase C-terminal domain; Beta-galactosidase; COGs: COG1874 Beta-galactosidase; InterPro IPR013529:IPR013738:IPR013739; KEGG: sta:STHERM_c03920 beta-galactosidase; PFAM: Glycoside hydrolase, family 42, N-terminal; Beta-galactosidase trimerisation; Beta-galactosidase C-terminal; SPTR: Beta-galactosidase.
 
  
 0.638
AEJ60651.1
PFAM: Glycosyl hydrolase family 3 C terminal domain; Fascin domain; Glycosyl hydrolase family 3 N terminal domain; COGs: COG1472 Beta-glucosidase-related glycosidase; InterPro IPR001764:IPR002772; KEGG: sta:STHERM_c04000 glucan 1,4-beta-glucosidase; PFAM: Glycoside hydrolase, family 3, C-terminal; Glycoside hydrolase, family 3, N-terminal; SPTR: Beta-glucosidase; manually curated.
 
   
 0.595
AEJ60645.1
PFAM: Glycosyl hydrolase family 53; COGs: COG3867 Arabinogalactan endo-1 4-beta-galactosidase; InterPro IPR011683; KEGG: sta:STHERM_c03950 arabinogalactan endo-1,4-beta-galactosidase; PFAM: Glycosyl hydrolase 53; SPTR: Arabinogalactan endo-1,4-beta-galactosidase.
 
  
 0.586
AEJ62372.1
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
    
 
 0.584
AEJ60847.1
Heat shock protein DnaJ domain protein; PFAM: DnaJ domain; InterPro IPR001623; KEGG: sta:STHERM_c05450 hypothetical protein; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Heat shock protein DnaJ domain protein.
   
 
 0.573
AEJ61281.1
Heat shock protein DnaJ domain protein; PFAM: DnaJ domain; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623; KEGG: sta:STHERM_c09840 molecular chaperone protein; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Heat shock protein DnaJ domain protein.
   
 
 0.573
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
   
 
 0.573
AEJ61645.1
PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771:IPR011289; KEGG: sta:STHERM_c07850 fructose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II; SPTR: Fructose-bisphosphate aldolase; TIGRFAM: Fructose-1,6-bisphosphate aldolase, class II; Ketose-bisphosphate aldolase, class-II.
   
   0.523
AEJ60652.1
Transcriptional regulator with cupin sensor, AraC family; PFAM: AraC-like ligand binding domain; Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR018060:IPR013096:IPR000005; KEGG: sta:STHERM_c04010 transcriptional regulator, AraC/XylS family; PFAM: Helix-turn-helix, AraC type; Cupin 2, conserved barrel; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
     
 0.520
rplK
Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
    
 
 0.518
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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