Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ60684.1PFAM: Xylose isomerase-like TIM barrel; COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307; KEGG: sta:STHERM_c04340 xylose isomerase domain-containing protein TIM barrel; PFAM: Xylose isomerase, TIM barrel domain; SPTR: Xylose isomerase domain-containing protein TIM barrel. (291 aa)    
Predicted Functional Partners:
AEJ60682.1
PfkB domain protein; PFAM: pfkB family carbohydrate kinase; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611; KEGG: sta:STHERM_c04320 carbohydrate kinase, PfkB family; PFAM: Carbohydrate/purine kinase; SPTR: PfkB domain protein.
  
  
 0.820
AEJ60683.1
PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase; COGs: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; InterPro IPR000887; KEGG: sta:STHERM_c04330 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; PFAM: KDPG/KHG aldolase; SPTR: 2-keto-3-deoxy-phosphogluconate aldolase.
       0.786
AEJ60685.1
KEGG: sta:STHERM_c04350 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
AEJ61616.1
PFAM: Glycosyl Hydrolase Family 88; COGs: COG4225 unsaturated glucuronyl hydrolase involved in regulation of surface properties and related protein; InterPro IPR010905; KEGG: sta:STHERM_c08190 glycosyl hydrolase, family 88; PFAM: Glycosyl hydrolase, family 88; SPTR: Glycosyl hydrolase family 88.
 
    0.726
AEJ60661.1
PFAM: Glycosyl Hydrolase Family 88; COGs: COG4225 unsaturated glucuronyl hydrolase involved in regulation of surface properties and related protein; InterPro IPR010905; KEGG: sta:STHERM_c04120 unsaturated glucuronyl hydrolase; PFAM: Glycosyl hydrolase, family 88; SPTR: Glycosyl hydrolase family 88.
 
    0.699
AEJ60681.1
PFAM: Glycosyl hydrolases family 28; COGs: COG5434 Endopygalactorunase; InterPro IPR006626:IPR000743; KEGG: sta:STHERM_c04310 hypothetical protein; PFAM: Glycoside hydrolase, family 28; SPTR: Glycoside hydrolase family 28.
 
     0.667
kduI
4-deoxy-L-threo-5-hexosulose-uronateketol- isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.
 
   
 0.639
AEJ61617.1
PFAM: Family 4 glycosyl hydrolase; Family 4 glycosyl hydrolase C-terminal domain; COGs: COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase family 4 of glycosyl hydrolase; InterPro IPR001088; KEGG: sta:STHERM_c08180 hydrolytic enzyme; PFAM: Glycoside hydrolase, family 4; SPTR: Glycoside hydrolase family 4.
  
     0.525
AEJ60686.1
PFAM: Tetratricopeptide repeat; Protein of unknown function (DUF1570); InterPro IPR019734:IPR013105:IPR001440; KEGG: sta:STHERM_c04360 hypothetical protein; PFAM: Tetratricopeptide TPR2; Tetratricopeptide TPR-1; SMART: Tetratricopeptide repeat; SPTR: Tetratricopeptide TPR_1 repeat-containing protein.
       0.497
aroE
3-dehydroquinate dehydratase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
   
 0.478
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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