STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60688.1PFAM: RNA pseudouridylate synthase; TIGRFAM: pseudouridine synthase, RluA family; COGs: COG0564 Pseudouridylate synthase 23S RNA-specific; InterPro IPR002942:IPR006145; KEGG: sta:STHERM_c04380 ribosomal large subunit pseudouridine synthase C; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; RNA-binding S4; SPTR: Pseudouridine synthase. (300 aa)    
Predicted Functional Partners:
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
 
 
 
 0.751
rplM
Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
 
   0.711
rplO
Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
 
   0.703
mnmE
tRNA modification GTPase mnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
  
 
 0.695
obg
GTPase obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
 
 
 
 0.686
rsfS
Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
  
 
 0.679
AEJ62168.1
PFAM: SpoU rRNA Methylase family; TIGRFAM: rRNA methylase, putative, group 3; COGs: COG0566 rRNA methylase; InterPro IPR001537:IPR004441; KEGG: sta:STHERM_c18660 rRNA methylase; PFAM: tRNA/rRNA methyltransferase, SpoU; SPTR: RNA methyltransferase, TrmH family, group 3; TIGRFAM: RNA methyltransferase TrmH, group 3; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
 
 
 0.668
rplK
Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
 
 0.665
rplQ
PFAM: Ribosomal protein L17; TIGRFAM: ribosomal protein L17; COGs: COG0203 Ribosomal protein L17; HAMAP: 50S ribosomal protein L17; InterPro IPR000456; KEGG: sta:STHERM_c05220 50S ribosomal protein L17; PFAM: Ribosomal protein L17; SPTR: 50S ribosomal protein L17; TIGRFAM: Ribosomal protein L17.
   
   0.665
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
   0.665
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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