Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
uxaCPFAM: Glucuronate isomerase; COGs: COG1904 Glucuronate isomerase; HAMAP: Uronate isomerase; InterPro IPR003766; KEGG: sta:STHERM_c04600 uronate isomerase; PFAM: Uronate isomerase; SPTR: Uronate isomerase. (469 aa)    
Predicted Functional Partners:
uxuA
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
 
  
 0.970
AEJ60685.1
KEGG: sta:STHERM_c04350 hypothetical protein; SPTR: Putative uncharacterized protein.
 
  
 0.925
AEJ61617.1
PFAM: Family 4 glycosyl hydrolase; Family 4 glycosyl hydrolase C-terminal domain; COGs: COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase family 4 of glycosyl hydrolase; InterPro IPR001088; KEGG: sta:STHERM_c08180 hydrolytic enzyme; PFAM: Glycoside hydrolase, family 4; SPTR: Glycoside hydrolase family 4.
 
  
  0.915
AEJ60896.1
PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149; KEGG: sta:STHERM_c06020 hypothetical protein; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; SPTR: Alcohol dehydrogenase GroES domain protein.
     
 0.908
AEJ61025.1
alpha-L-arabinofuranosidase domain protein; PFAM: Alpha-L-arabinofuranosidase C-terminus; COGs: COG3534 Alpha-L-arabinofuranosidase; InterPro IPR010720; KEGG: sta:STHERM_c14770 alpha-N-arabinofuranosidase; PFAM: Alpha-L-arabinofuranosidase, C-terminal; SMART: Alpha-L-arabinofuranosidase, C-terminal; SPTR: Alpha-N-arabinofuranosidase.
   
 
 0.820
AEJ61026.1
alpha-L-arabinofuranosidase domain protein; PFAM: Alpha-L-arabinofuranosidase C-terminus; COGs: COG3534 Alpha-L-arabinofuranosidase; InterPro IPR010720; KEGG: sta:STHERM_c14760 alpha-N-arabinofuranosidase 2; PFAM: Alpha-L-arabinofuranosidase, C-terminal; SMART: Alpha-L-arabinofuranosidase, C-terminal; SPTR: Alpha-L-arabinofuranosidase domain protein.
   
 
 0.820
AEJ62151.1
PFAM: Glycosyl hydrolases family 43; COGs: COG3507 Beta-xylosidase; InterPro IPR006710; KEGG: sta:STHERM_c18500 beta-xylosidase; PFAM: Glycoside hydrolase, family 43; SPTR: Xylan 1,4-beta-xylosidase.
    
 0.812
AEJ60298.1
Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR001732:IPR014026:IPR014027:IPR017476; KEGG: sta:STHERM_c00110 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; SPTR: Nucleo [...]
     
  0.800
AEJ60700.1
Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: sta:STHERM_c04590 D-mannonate oxidoreductase; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR.
 
   
 0.798
AEJ60683.1
PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase; COGs: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; InterPro IPR000887; KEGG: sta:STHERM_c04330 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; PFAM: KDPG/KHG aldolase; SPTR: 2-keto-3-deoxy-phosphogluconate aldolase.
 
   
 0.607
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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