STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AEJ60769.1Small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: hydrogenase maturation GTPase HydF; small GTP-binding protein domain; COGs: COG1160 GTPase; InterPro IPR005225:IPR002917; KEGG: sta:STHERM_c17970 hypothetical protein; PFAM: GTP-binding protein, HSR1-related; SPTR: Small GTP-binding protein; TIGRFAM: Small GTP-binding protein. (411 aa)    
Predicted Functional Partners:
AEJ60767.1
PFAM: Radical SAM superfamily; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydE; COGs: COG0502 Biotin synthase; InterPro IPR006638:IPR007197; KEGG: sta:STHERM_c17990 hypothetical protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
   
 0.991
AEJ60766.1
PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydG; thiazole biosynthesis protein ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197:IPR010722; KEGG: sta:STHERM_c18000 hypothetical protein; PFAM: Biotin/thiamin synthesis-associated protein; Radical SAM; SPTR: Iron-only hydrogenase maturation protein HydG.
   
 0.967
AEJ60765.1
Transcriptional regulator, CopG family; TIGRFAM: putative iron-only hydrogenase system regulator; KEGG: sta:STHERM_c18010 transcriptional regulator, CopG family; SPTR: Putative uncharacterized protein.
 
   
 0.897
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
  
 0.808
AEJ61770.1
Hydrogenase, Fe-only; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Iron only hydrogenase large subunit, C-terminal domain; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Iron hydrogenase small subunit; TIGRFAM: hydrogenase, Fe-only; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR001041:IPR019574:IPR001450:IPR004108:IPR 003149:IPR013352; KEGG: sta:STHERM_c13740 hypothetical protein; PFAM: Iron hydrogenase, large subunit, C-terminal; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; Ferredoxin; 4Fe-4S ferredoxin, iron-sulp [...]
 
   
 0.781
gpsA
PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; COGs: COG0240 Glycerol-3-phosphate dehydrogenase; HAMAP: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; InterPro IPR011128:IPR006109; KEGG: sta:STHERM_c21120 hypothetical protein; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal; NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal; SPTR: Glycerol-3-phosphate dehydrogenase.
  
  
 0.775
AEJ60920.1
Hydrogenase, Fe-only; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Iron only hydrogenase large subunit, C-terminal domain; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Iron hydrogenase small subunit; TIGRFAM: hydrogenase, Fe-only; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR013352:IPR001041:IPR019574:IPR001450:IPR 004108:IPR003149; KEGG: sta:STHERM_c06260 hypothetical protein; PFAM: Iron hydrogenase, large subunit, C-terminal; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; Ferredoxin; 4Fe-4S ferredoxin, iron-sulp [...]
 
   
 0.747
AEJ60768.1
PFAM: Lyase; COGs: COG1027 Aspartate ammonia-lyase; InterPro IPR000362; KEGG: sta:STHERM_c17980 aspartate ammonia-lyase AspA; PFAM: Fumarate lyase; SPTR: Fumarate lyase.
 
  
 0.721
AEJ61539.1
Fe-S cluster domain protein; PFAM: Iron only hydrogenase large subunit, C-terminal domain; Putative Fe-S cluster; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR001450:IPR007202; KEGG: sta:STHERM_c12360 hypothetical protein; PFAM: Putative Fe-S cluster; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Fe-S cluster domain protein.
 
   
 0.667
AEJ60421.1
Thiazole biosynthesis protein ThiH; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197:IPR010722:IPR012726; KEGG: sta:STHERM_c01460 hypothetical protein; PFAM: Biotin/thiamin synthesis-associated protein; Radical SAM; SPTR: Tyrosine lyase ThiH; TIGRFAM: Thiazole biosynthesis ThiH.
   
 0.606
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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