STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (143 aa)    
Predicted Functional Partners:
AEJ60826.1
Methyltransferase type 11; PFAM: Methyltransferase domain; InterPro IPR013216; KEGG: sta:STHERM_c05240 SAM-dependent methyltransferase; PFAM: Methyltransferase type 11; SPTR: Methyltransferase type 11.
     
 0.785
AEJ60825.1
KEGG: sta:STHERM_c05230 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
      0.738
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.727
rnhB
Ribonuclease HII/HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.724
AEJ61114.1
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
   
 
 0.704
AEJ60828.1
PFAM: Magnesium chelatase, subunit ChlI; Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: Mg chelatase-related protein; COGs: COG0606 ATPase with chaperone activity; InterPro IPR004482:IPR003593:IPR000523; KEGG: sta:STHERM_c05260 hypothetical protein; PFAM: Magnesium chelatase, ChlI subunit; SMART: ATPase, AAA+ type, core; SPTR: Mg chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein.
       0.685
AEJ61383.1
Protein of unknown function DUF164; PFAM: Putative zinc ribbon domain; COGs: COG1579 Zn-ribbon protein possibly nucleic acid-binding; InterPro IPR003743; KEGG: sta:STHERM_c10830 nucleic acid-binding Zn-ribbon protein; PFAM: Protein of unknown function DUF164; SPTR: Putative uncharacterized protein.
  
  
 0.599
rplQ
PFAM: Ribosomal protein L17; TIGRFAM: ribosomal protein L17; COGs: COG0203 Ribosomal protein L17; HAMAP: 50S ribosomal protein L17; InterPro IPR000456; KEGG: sta:STHERM_c05220 50S ribosomal protein L17; PFAM: Ribosomal protein L17; SPTR: 50S ribosomal protein L17; TIGRFAM: Ribosomal protein L17.
     
 0.565
uvrB
UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...]
     
 0.546
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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