STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AEJ60840.1Phosphate uptake regulator, PhoU; Plays a role in the regulation of phosphate uptake. (217 aa)    
Predicted Functional Partners:
AEJ60834.1
PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: phosphate ABC transporter, permease protein PstA; COGs: COG0581 ABC-type phosphate transport system permease component; InterPro IPR005672:IPR000515; KEGG: sta:STHERM_c05320 transporter; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Phosphate ABC transporter membrane protein 2, PhoT family; TIGRFAM: Phosphate transport system permease protein 2.
 
  
 0.981
pstB
Phosphate ABC transporter, ATPase subunit; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
 
  
 0.981
AEJ60838.1
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG5002 Signal transduction histidine kinase; InterPro IPR000014:IPR003661:IPR003594:IPR013656; KEGG: sta:STHERM_c05360 phosphate regulon sensor protein PhoR; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS; SPTR [...]
 
   
 0.867
AEJ60832.1
TIGRFAM: phosphate binding protein; COGs: COG0226 ABC-type phosphate transport system periplasmic component; InterPro IPR011862; KEGG: sta:STHERM_c05300 phosphate ABC transporter phosphate-binding protein; SPTR: Phosphate ABC transporter substrate-binding protein, PhoT family; TIGRFAM: Phosphate binding protein.
 
  
 0.857
AEJ60833.1
Phosphate ABC transporter, inner membrane subunit PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
 
  
 0.847
AEJ60839.1
Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: sta:STHERM_c05370 transcriptional regulatory protein; PFAM: Signal transduction response regulator, receiver region; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver region; SPTR: Two component transcriptional regulator, winged he [...]
  
  
 0.823
AEJ60841.1
KEGG: sta:STHERM_c05400 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.550
kduI
4-deoxy-L-threo-5-hexosulose-uronateketol- isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.
   
    0.522
AEJ60577.1
Hypothetical protein; PFAM: Omptin family; COGs: COG4571 Outer membrane protease; KEGG: sta:STHERM_c03080 hypothetical protein; SPTR: Putative uncharacterized protein.
   
    0.474
AEJ62495.1
RNA polymerase, sigma 54 subunit, RpoN; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54 factor, core binding domain; Sigma-54, DNA binding domain; TIGRFAM: RNA polymerase sigma-54 factor; COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: sta:STHERM_c21940 RNA polymerase sigma-54 factor; PFAM: RNA polymerase sigma factor 54, DNA-binding; RNA polymerase sigma factor 54; RNA polymerase sigma factor 54, core-binding; SPTR: RNA polymerase, sigma 54 subunit, RpoN; TIGRFAM: RNA polymerase sigm [...]
  
  
 0.441
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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