STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60846.1Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR003593:IPR002078:IPR002197; KEGG: sta:STHERM_c05440 transcriptional regulatory protein; PFAM: RNA polymerase sigma factor 54, interaction; Signal transduction response regulator, receiver region; Helix-turn-helix, Fis-type; SMART: Signal transduction response regulator, receiver r [...] (453 aa)    
Predicted Functional Partners:
AEJ60845.1
Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG3852 Signal transduction histidine kinase nitrogen specific; InterPro IPR000014:IPR003661:IPR003594:IPR013656; KEGG: sta:STHERM_c05430 sensory transduction histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; SMART: ATP-binding region, ATPase-like; Signal transduction histidine [...]
 
 0.951
AEJ60844.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: sta:STHERM_c05420 DNA polymerase III domain-containing protein; SPTR: Putative uncharacterized protein.
       0.786
AEJ61223.1
Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.
  
  
 0.785
murG
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
     
 0.774
AEJ62495.1
RNA polymerase, sigma 54 subunit, RpoN; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54 factor, core binding domain; Sigma-54, DNA binding domain; TIGRFAM: RNA polymerase sigma-54 factor; COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: sta:STHERM_c21940 RNA polymerase sigma-54 factor; PFAM: RNA polymerase sigma factor 54, DNA-binding; RNA polymerase sigma factor 54; RNA polymerase sigma factor 54, core-binding; SPTR: RNA polymerase, sigma 54 subunit, RpoN; TIGRFAM: RNA polymerase sigm [...]
 
   
 0.772
AEJ60843.1
PFAM: Colicin V production protein; InterPro IPR003825; KEGG: sta:STHERM_c05410 hypothetical protein; PFAM: Colicin V production protein; SPTR: Colicin V production protein.
       0.768
AEJ61711.1
PAS/PAC sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterPro IPR000014:IPR003661:IPR003594; KEGG: sta:STHERM_c07090 sensor protein ZraS; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PA [...]
 
 
 
 0.716
AEJ60614.1
Multi-sensor signal transduction histidine kinase; PFAM: Ammonium Transporter Family; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hpt domain; TIGRFAM: ammonium transporter; COGs: COG0004 Ammonia permease; InterPro IPR001905:IPR003594:IPR013767:IPR008207; KEGG: sta:STHERM_c03600 ammonia permease with sensory box/GGDEF domains; PFAM: Ammonium transporter; PAS fold; Signal transduction histidine kinase, phosphotransfer (Hpt) region; ATP-binding region, ATPase-like; SMART: ATP-binding region, ATPase-like; SPTR: Multi-sensor signal transduction histidine kinase; TIGRFAM: Ammoni [...]
  
 
 0.675
AEJ62052.1
MCP methyltransferase, CheR-type; PFAM: CheW-like domain; CheR methyltransferase, SAM binding domain; COGs: COG0835 Chemotaxis signal transduction protein; InterPro IPR002545:IPR000780; KEGG: sta:STHERM_c17220 chemotaxis protein CheW; PFAM: MCP methyltransferase, CheR-type; CheW-like protein; SMART: CheW-like protein; MCP methyltransferase, CheR-type; SPTR: MCP methyltransferase, CheR-type.
  
  
 0.583
AEJ61459.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR001789:IPR013767:IPR003661:IPR003594:IPR 000014; KEGG: sta:STHERM_c11530 hypothetical protein; PFAM: ATP-binding region, ATPase-like; Signal transduction response regulator, receiver region; PAS fold; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: Signal transdu [...]
 
 0.553
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.