Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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AEJ60849.1Helicase c2; PFAM: Protein of unknown function (DUF2466); DEAD/DEAH box helicase; TIGRFAM: DnaQ family exonuclease/DinG family helicase, putative; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006555; KEGG: sta:STHERM_c05470 hypothetical protein; SMART: Helicase, ATP-dependent, c2 type; SPTR: Helicase c2. (809 aa)    
Predicted Functional Partners:
AEJ61501.1
PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family; COGs: COG2176 DNA polymerase III alpha subunit (gram-positive type); InterPro IPR006055:IPR013520:IPR006054; KEGG: sta:STHERM_c11930 hypothetical protein; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease; SPTR: DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit.
      0.907
AEJ60579.1
PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR006935:IPR001650:IPR014001; KEGG: sta:STHERM_c03100 DNA-helicase; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Type III restriction protein res subunit.
   
 0.882
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.874
AEJ60289.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.818
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.791
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.775
AEJ61524.1
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
  0.660
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.580
AEJ60848.1
PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; COGs: COG0527 Aspartokinase; InterPro IPR001341:IPR001048; KEGG: sta:STHERM_c05460 aspartokinase 3; PFAM: Aspartate/glutamate/uridylate kinase; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase region.
       0.579
AEJ60535.1
Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; InterPro IPR004843; KEGG: sta:STHERM_c02680 hydrolase; PFAM: Metallophosphoesterase; SPTR: Metallophosphoesterase.
   
 0.555
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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