STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ60873.1Rieske (2Fe-2S) iron-sulfur domain-containing protein; PFAM: Rieske [2Fe-2S] domain; COGs: COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenase; InterPro IPR017941; KEGG: sta:STHERM_c05740 hypothetical protein; PFAM: Rieske [2Fe-2S] iron-sulphur domain; SPTR: Putative uncharacterized protein. (91 aa)    
Predicted Functional Partners:
AEJ61561.1
PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR008333:IPR001433:IPR019480; KEGG: sta:STHERM_c12580 hypothetical protein; PFAM: Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase FAD-binding region; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Sulfide dehydrogenase (Flavoprotein) subunit SudB.
    
 0.913
AEJ61934.1
uroporphyrin-III C-methyltransferase; PFAM: Porphobilinogen deaminase, dipyromethane cofactor binding domain; Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: porphobilinogen deaminase; uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000860:IPR000878:IPR003754; KEGG: sta:STHERM_c16140 porphyrin biosynthesis protein HemD; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, hydroxymethylbilane synthase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrin-III C-m [...]
  
  
 0.875
AEJ60990.1
PFAM: Pyridine nucleotide-disulphide oxidoreductase; DsrE/DsrF-like family; SirA-like protein; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Rhodanese-like domain; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; InterProIPR013027:IPR004099:IPR001763:IPR001455:IPR 014865; KEGG: sta:STHERM_c15100 hypothetical protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; Rhodanese-like; SirA-like; Protein of unknown function DUF1791; SMART: Rhodanese-like; SPTR: FAD-dependent pyridine nucleoti [...]
  
 
 0.810
AEJ60874.1
Cysteine desulfurase, SufS subfamily; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
       0.796
AEJ60875.1
PFAM: NifU-like N terminal domain; TIGRFAM: SUF system FeS assembly protein, NifU family; COGs: COG0822 NifU homolog involved in Fe-S cluster formation; InterPro IPR011341:IPR002871; KEGG: sta:STHERM_c05760 hypothetical protein; PFAM: NIF system FeS cluster assembly, NifU, N-terminal; SPTR: SUF system FeS assembly protein, NifU family; TIGRFAM: SUF system FeS cluster assembly, SufU scaffold.
       0.796
AEJ60872.1
SufBD protein; PFAM: Uncharacterized protein family (UPF0051); COGs: COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component; InterPro IPR000825; KEGG: sta:STHERM_c05730 hypothetical protein; PFAM: SUF system FeS cluster assembly, SufBD; SPTR: SufBD protein.
       0.795
AEJ60871.1
FeS assembly protein SufB; PFAM: Uncharacterized protein family (UPF0051); TIGRFAM: FeS assembly protein SufB; COGs: COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component; InterPro IPR010231:IPR000825; KEGG: sta:STHERM_c05720 hypothetical protein; PFAM: SUF system FeS cluster assembly, SufBD; SPTR: Iron-regulated ABC transporter membrane component SufB; TIGRFAM: SUF system FeS cluster assembly, SufB.
       0.794
AEJ60870.1
PFAM: ABC transporter; TIGRFAM: FeS assembly ATPase SufC; COGs: COG0396 ABC-type transport system involved in Fe-S cluster assembly ATPase component; InterPro IPR010230:IPR003593:IPR003439; KEGG: sta:STHERM_c05710 transporter; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: FeS assembly ATPase SufC; TIGRFAM: ATPase SufC, SUF system FeS cluster assembly.
       0.778
AEJ60869.1
PFAM: Domain of unknown function DUF59; COGs: COG2151 metal-sulfur cluster biosynthetic protein; InterPro IPR002744; KEGG: sta:STHERM_c05700 metal-sulfur cluster biosynthetic enzyme; PFAM: Protein of unknown function DUF59; SPTR: Putative uncharacterized protein.
       0.776
AEJ60868.1
PFAM: Transcriptional regulator; TIGRFAM: Rrf2 family protein; COGs: COG1959 transcriptional regulator protein; InterPro IPR000944; KEGG: sta:STHERM_c05690 hypothetical protein; PFAM: Transcriptional regulator, Rrf2; SPTR: Transcriptional regulator, BadM/Rrf2 family.
       0.751
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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