Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ61005.1PFAM: Cytochrome b5-like Heme/Steroid binding domain; InterPro IPR001199; KEGG: sta:STHERM_c14910 soluble cytochrome b558; PFAM: Cytochrome b5; SPTR: Cytochrome b5. (133 aa)    
Predicted Functional Partners:
AEJ62063.1
PFAM: Nucleoside diphosphate kinase; COGs: COG0105 Nucleoside diphosphate kinase; InterPro IPR001564; KEGG: sta:STHERM_c17330 nucleoside-diphosphate kinase; PFAM: Nucleoside diphosphate kinase, core; SMART: Nucleoside diphosphate kinase, core; SPTR: Nucleoside diphosphate kinase; Belongs to the NDK family.
  
 
 
 0.796
AEJ61006.1
KEGG: sta:STHERM_c14900 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
AEJ60761.1
PFAM: Histone deacetylase domain; COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: sta:STHERM_c18020 histone deacetylase superfamily; PFAM: Histone deacetylase superfamily; SPTR: Histone deacetylase superfamily.
    
 
 0.771
AEJ61247.1
PFAM: Ankyrin repeat; COGs: COG0666 FOG: Ankyrin repeat; InterPro IPR002110; KEGG: sta:STHERM_c09480 ankyrin repeat-containing protein; PFAM: Ankyrin repeat; SMART: Ankyrin repeat; SPTR: Ankyrin.
    
 
 0.770
AEJ61119.1
WD40 repeat-containing protein; PFAM: WD domain, G-beta repeat; InterPro IPR019781:IPR001680; KEGG: sta:STHERM_c13130 hypothetical protein; PFAM: WD40 repeat, subgroup; SMART: WD40 repeat; SPTR: WD40 repeat, subgroup.
    
 
 0.768
AEJ61442.1
TIGRFAM: small redox-active disulfide protein 2; InterPro IPR005243; KEGG: sta:STHERM_c11400 redox-active disulfide protein 2; SPTR: Redox-active disulfide protein 2; TIGRFAM: Redox-active disulphide protein 2.
    
 
 0.665
AEJ60847.1
Heat shock protein DnaJ domain protein; PFAM: DnaJ domain; InterPro IPR001623; KEGG: sta:STHERM_c05450 hypothetical protein; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Heat shock protein DnaJ domain protein.
    
   0.655
AEJ61281.1
Heat shock protein DnaJ domain protein; PFAM: DnaJ domain; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623; KEGG: sta:STHERM_c09840 molecular chaperone protein; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Heat shock protein DnaJ domain protein.
    
   0.655
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
    
   0.655
AEJ62506.1
Tetratricopeptide TPR_2 repeat-containing protein; PFAM: Tetratricopeptide repeat; COGs: COG0457 FOG: TPR repeat; InterPro IPR001440:IPR013105:IPR019734; KEGG: sta:STHERM_c22050 TPR domain-containing protein; PFAM: Tetratricopeptide TPR2; Tetratricopeptide TPR-1; SPTR: Tetratricopeptide TPR_1 repeat-containing protein.
  
 
 0.585
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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