STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
birAbiotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (304 aa)    
Predicted Functional Partners:
AEJ60767.1
PFAM: Radical SAM superfamily; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydE; COGs: COG0502 Biotin synthase; InterPro IPR006638:IPR007197; KEGG: sta:STHERM_c17990 hypothetical protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
 
 
 0.947
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 
 0.940
AEJ62306.1
PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region; COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR004143:IPR004408; KEGG: sta:STHERM_c19990 hypothetical protein; PFAM: Biotin/lipoate A/B protein ligase; SPTR: Biotin/acetyl-CoA-carboxylase ligase; TIGRFAM: Biotin--acetyl-CoA-carboxylase ligase.
 
 
 
0.931
AEJ61664.1
Universal protein YeaZ; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: sta:STHERM_c07660 peptidase M22, glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Peptidase M22 glycoprotease; TIGRFAM: universal protein YeaZ.
 
    0.916
AEJ61060.1
PFAM: BioY family; COGs: COG1268 conserved hypothetical protein; InterPro IPR003784; KEGG: sta:STHERM_c14470 biotin synthesis protein BioY; PFAM: BioY protein; SPTR: BioY protein.
 
   
 0.884
AEJ62230.1
Exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth); COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR004808:IPR000097; KEGG: sta:STHERM_c19260 hypothetical protein; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Exodeoxyribonuclease III Xth; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1.
  
    0.864
AEJ61580.1
PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase subunit; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR005481:IPR005479:IPR005482:IPR004549; KEGG: sta:STHERM_c08570 pyruvate carboxylase subunit A; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal; SPTR: Biotin carboxylase; acetyl-CoA carboxylase [...]
  
 0.789
AEJ62455.1
Biotin/lipoyl attachment domain-containing protein; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000891:IPR000089; KEGG: sta:STHERM_c21570 pyruvate carboxylase, beta chain; PFAM: Biotin/lipoyl attachment; Pyruvate carboxyltransferase; SPTR: Biotin/lipoyl attachment domain-containing protein.
   
 
 0.749
AEJ61058.1
ABC-type transporter, integral membrane subunit; PFAM: Cobalt transport protein; InterPro IPR003339; KEGG: sta:STHERM_c14490 hypothetical protein; PFAM: Cobalt transport protein; SPTR: Cobalt transport protein.
 
   
 0.743
AEJ61581.1
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
   
 
 0.739
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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