STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61068.1PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: sta:STHERM_c14400 aspartate aminotransferase; PFAM: Aminotransferase, class I/II; SPTR: Aminotransferase class I and II. (415 aa)    
Predicted Functional Partners:
ilvD
PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: sta:STHERM_c14560 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.919
AEJ62062.1
Amino-acid N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family; Amino acid kinase family; TIGRFAM: amino-acid N-acetyltransferase; COGs: COG0548 Acetylglutamate kinase; InterPro IPR010167:IPR001048:IPR000182; KEGG: sta:STHERM_c17320 amino acid acetyltransferase; PFAM: GCN5-related N-acetyltransferase; Aspartate/glutamate/uridylate kinase; SPTR: Amino-acid N-acetyltransferase; TIGRFAM: Amino-acid N-acetyltransferase (ArgA); Belongs to the acetyltransferase family.
  
 
 0.916
AEJ60449.1
PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544:IPR005786; KEGG: sta:STHERM_c01780 branched-chain-amino-acid aminotransferase; PFAM: Aminotransferase, class IV; SPTR: Branched-chain-amino-acid aminotransferase; TIGRFAM: Branched-chain amino acid aminotransferase II; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.913
argJ
Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
    
 0.909
AEJ61241.1
PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709:IPR005675; KEGG: sta:STHERM_c09420 AIPM/Hcit synthase family transferase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SPTR: (R)-citramalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase related; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.906
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.906
AEJ61982.1
PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: sta:STHERM_c16630 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin ox [...]
  
 
 0.890
AEJ60389.1
PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015794:IPR001697; KEGG: sta:STHERM_c01140 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase.
   
 0.832
AEJ60917.1
Malic protein NAD-binding protein; PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302; KEGG: sta:STHERM_c06230 hypothetical protein; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; SPTR: Malic protein NAD-binding.
  
 0.830
AEJ62455.1
Biotin/lipoyl attachment domain-containing protein; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000891:IPR000089; KEGG: sta:STHERM_c21570 pyruvate carboxylase, beta chain; PFAM: Biotin/lipoyl attachment; Pyruvate carboxyltransferase; SPTR: Biotin/lipoyl attachment domain-containing protein.
    
 0.830
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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