STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AEJ61101.1Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (1239 aa)    
Predicted Functional Partners:
AEJ60553.1
PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I; COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR004809; KEGG: sta:STHERM_c02830 glutamine synthetase, type 1; PFAM: Glutamine synthetase, catalytic region; Glutamine synthetase, beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: Glutamine synthetase type I.
 
  
 0.861
AEJ61109.1
PFAM: Nitrogen regulatory protein P-II; COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR002187; KEGG: sta:STHERM_c13230 transcriptional regulatory protein; PFAM: Nitrogen regulatory protein PII; SPTR: Nitrogen regulatory protein P-II.
   
 
 0.805
AEJ61321.1
PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: sta:STHERM_c10240 glutamate synthase; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; SPTR: Glutamate synthase (NADH) large subunit.
     
 0.719
bioD
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
       0.617
AEJ61106.1
PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814; KEGG: sta:STHERM_c13250 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; SPTR: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; manually curated; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.591
AEJ61103.1
Methyltransferase type 11; PFAM: Methyltransferase domain; TIGRFAM: biotin biosynthesis protein BioC; InterPro IPR013216; KEGG: sta:STHERM_c13280 biotin biosynthesis protein BioC; PFAM: Methyltransferase type 11; SPTR: Methyltransferase type 11.
       0.559
AEJ61104.1
PFAM: Protein of unknown function (DUF452); COGs: COG2830 conserved hypothetical protein; InterPro IPR007398; KEGG: sta:STHERM_c13270 hypothetical protein; PFAM: Protein of unknown function DUF452; SPTR: Putative uncharacterized protein.
       0.559
AEJ61105.1
PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: sta:STHERM_c13260 hypothetical protein; PFAM: Aminotransferase, class I/II; SPTR: 8-amino-7-oxononanoate synthase.
       0.557
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.533
AEJ60370.1
Hemagluttinin repeat-containing protein; InterPro IPR008619; KEGG: sta:STHERM_c00960 hypothetical protein; PFAM: Filamentous haemagglutinin, bacterial; SPTR: Hemagluttinin repeat-containing protein.
  
   
 0.475
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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