STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61106.1PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814; KEGG: sta:STHERM_c13250 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; SPTR: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; manually curated; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (479 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 0.999
AEJ61105.1
PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: sta:STHERM_c13260 hypothetical protein; PFAM: Aminotransferase, class I/II; SPTR: 8-amino-7-oxononanoate synthase.
 
 
 0.996
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 0.977
AEJ62342.1
PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: sta:STHERM_c20440 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase, class I/II; SPTR: Serine palmitoyltransferase.
 
 
 0.974
AEJ61103.1
Methyltransferase type 11; PFAM: Methyltransferase domain; TIGRFAM: biotin biosynthesis protein BioC; InterPro IPR013216; KEGG: sta:STHERM_c13280 biotin biosynthesis protein BioC; PFAM: Methyltransferase type 11; SPTR: Methyltransferase type 11.
 
     0.887
AEJ61104.1
PFAM: Protein of unknown function (DUF452); COGs: COG2830 conserved hypothetical protein; InterPro IPR007398; KEGG: sta:STHERM_c13270 hypothetical protein; PFAM: Protein of unknown function DUF452; SPTR: Putative uncharacterized protein.
 
   
 0.853
AEJ60767.1
PFAM: Radical SAM superfamily; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydE; COGs: COG0502 Biotin synthase; InterPro IPR006638:IPR007197; KEGG: sta:STHERM_c17990 hypothetical protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
 
  
 0.793
AEJ61107.1
MULE transposase, conserved domain-containing protein; PFAM: Transposase, Mutator family; COGs: COG3328 Transposase and inactivated derivatives; InterPro IPR018289; KEGG: sta:STHERM_c22570 hypothetical protein; PFAM: MULE transposase, conserved domain; SPTR: MULE transposase, conserved domain.
       0.642
AEJ61101.1
Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
  
  
 0.591
AEJ61658.1
PFAM: FlaG protein; InterPro IPR005186; KEGG: sta:STHERM_c07720 hypothetical protein; PFAM: Flagellar protein FlaG protein; SPTR: Flagellar protein FlaG protein.
    
   0.543
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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