Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rny2,3 cyclic-nucleotide 2-phosphodiesterase; Endoribonuclease that initiates mRNA decay. (509 aa)    
Predicted Functional Partners:
AEJ62162.1
PSP1 domain protein; PFAM: PSP1 C-terminal conserved region; COGs: COG1774 Uncharacterized homolog of PSP1; InterPro IPR007557; KEGG: sta:STHERM_c18600 hypothetical protein; PFAM: PSP1, C-terminal; SPTR: PSP1 domain protein.
 
  
 0.743
AEJ61129.1
Conserved hypothetical protein CHP00282; TIGRFAM: metallophosphoesterase, MG_246/BB_0505 family; COGs: COG1692 conserved hypothetical protein; InterPro IPR005235:IPR004843; KEGG: sta:STHERM_c13020 hypothetical protein; PFAM: Metallophosphoesterase; SPTR: Metallophosphoesterase; TIGRFAM: Conserved hypothetical protein CHP00282.
  
  
 0.595
AEJ61130.1
PFAM: FtsJ-like methyltransferase; TIGRFAM: hemolysin TlyA family protein; COGs: COG1189 rRNA methylase; InterPro IPR004538:IPR002877; KEGG: sta:STHERM_c13010 hemolysin; PFAM: Ribosomal RNA methyltransferase RrmJ/FtsJ; SPTR: Hemolysin A; TIGRFAM: Haemolysin A.
  
    0.593
AEJ61127.1
Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
       0.507
rpsB
PFAM: Ribosomal protein S2; TIGRFAM: ribosomal protein S2, bacterial type; COGs: COG0052 Ribosomal protein S2; InterPro IPR005706:IPR001865; KEGG: sta:STHERM_c13060 30S ribosomal protein S2; PFAM: Ribosomal protein S2; SPTR: 30S ribosomal protein S2; TIGRFAM: Ribosomal protein S2, bacteria/mitochondria/plastid.
  
  
 0.492
pnp
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
 
 0.454
tsf
Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.
       0.437
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.407
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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