STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61160.1Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001926; KEGG: sta:STHERM_c12700 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase K/M; Cysteine synthase A. (318 aa)    
Predicted Functional Partners:
AEJ60514.1
Serine acetyltransferase; PFAM: Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: sta:STHERM_c02440 serine acetyltransferase; SPTR: Serine O-acetyltransferase.
 
 0.988
AEJ61941.1
PFAM: SirA-like protein; Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain; COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR005117:IPR006067:IPR001455; KEGG: sta:STHERM_c16210 ferredoxin-nitrite reductase; PFAM: Nitrite/sulphite reductase 4Fe-4S region; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; SirA-like; SPTR: Ferredoxin--nitrite reductase.
  
 
 0.972
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.915
AEJ61937.1
Sulfate adenylyltransferase, large subunit; PFAM: Elongation factor Tu domain 2; Elongation factor Tu GTP binding domain; Adenylylsulphate kinase; TIGRFAM: sulfate adenylyltransferase, large subunit; COGs: COG2895 GTPase - Sulfate adenylate transferase subunit 1; InterPro IPR011779:IPR000795:IPR004161; KEGG: sta:STHERM_c16170 sulfate adenylyltransferase large subunit; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; SPTR: Sulfate adenylyltransferase, large subunit; TIGRFAM: Sulphate adenylyltransferase, large subunit.
  
  
 0.904
cysS
PFAM: tRNA synthetases class I (C) catalytic domain; TIGRFAM: cysteinyl-tRNA synthetase; COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015803:IPR002308; KEGG: sta:STHERM_c18260 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia, N-terminal; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.904
AEJ61141.1
Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001926; KEGG: sta:STHERM_c12900 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M.
  
  
 
0.903
AEJ60486.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.875
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.849
AEJ61142.1
PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase; COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235:IPR000277; KEGG: sta:STHERM_c12890 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SPTR: O-acetylhomoserine sulfhydrolase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase.
  
 
 0.826
AEJ61946.1
PFAM: Cys/Met metabolism PLP-dependent enzyme; COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277; KEGG: sta:STHERM_c16260 O-acetylhomoserineaminocarboxypropyltransferase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SPTR: Cys/Met metabolism pyridoxal-phosphate-dependent protein.
  
 
 0.826
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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