STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
xerC-2Tyrosine recombinase xerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (312 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
  
 0.884
hslV
ATP-dependent protease hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
  
  
 0.876
AEJ61201.1
PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: sta:STHERM_c09020 DNA processing protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: DNA protecting protein DprA; TIGRFAM: DNA recombination-mediator protein A.
 
   
 0.855
xerC
Tyrosine recombinase xerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
 
   
0.847
hslU
ATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
  
  
 0.842
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
     
 0.825
AEJ61200.1
Tetratricopeptide TPR_1 repeat-containing protein; PFAM: Tetratricopeptide repeat; InterPro IPR001440:IPR019734; KEGG: sta:STHERM_c09010 TPR domain-containing protein; PFAM: Tetratricopeptide TPR-1; SMART: Tetratricopeptide repeat; SPTR: Tetratricopeptide TPR_1 repeat-containing protein.
       0.807
mraZ
PFAM: MraZ protein; TIGRFAM: mraZ protein; COGs: COG2001 conserved hypothetical protein; HAMAP: MraZ; InterPro IPR020603:IPR003444; KEGG: sta:STHERM_c08910 protein MraZ; PFAM: MraZ domain; SPTR: Protein MraZ; TIGRFAM: MraZ; Belongs to the MraZ family.
 
   
 0.768
ftsA
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
  
  
 0.745
AEJ61195.1
PFAM: Cell cycle protein; TIGRFAM: cell division protein FtsW; COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR001182:IPR013437; KEGG: sta:STHERM_c08960 hypothetical protein; PFAM: Cell cycle protein; SPTR: Cell division protein FtsW; TIGRFAM: Cell division protein FtsW; Belongs to the SEDS family.
  
  
 0.743
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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