STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61309.1RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (338 aa)    
Predicted Functional Partners:
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
  
 0.776
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.774
AEJ61310.1
PFAM: Cobalamin adenosyltransferase; TIGRFAM: ATP:cob(I)alamin adenosyltransferase; COGs: COG2096 conserved hypothetical protein; InterPro IPR002779:IPR017858; KEGG: sta:STHERM_c10130 hypothetical protein; PFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, EutT/PduO type; SPTR: ATP/cobalamin adenosyltransferase; TIGRFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, PduO-type, N-terminal.
       0.762
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.737
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.701
efp
Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
 
  
 0.687
AEJ61524.1
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.681
AEJ62201.1
PFAM: CarD-like/TRCF domain; COGs: COG1329 Transcriptional regulators similar to M. xanthus CarD; InterPro IPR003711; KEGG: sta:STHERM_c18970 transcriptional regulatory protein; PFAM: Transcription factor CarD; SPTR: Transcriptional regulator, CarD family.
   
 
 0.669
AEJ60652.1
Transcriptional regulator with cupin sensor, AraC family; PFAM: AraC-like ligand binding domain; Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR018060:IPR013096:IPR000005; KEGG: sta:STHERM_c04010 transcriptional regulator, AraC/XylS family; PFAM: Helix-turn-helix, AraC type; Cupin 2, conserved barrel; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
   
 
 0.614
AEJ61134.1
PFAM: MerR family regulatory protein; COGs: COG0789 transcriptional regulator protein; InterPro IPR000551; KEGG: sta:STHERM_c12970 transcriptional regulatory protein; PFAM: HTH transcriptional regulator, MerR; SMART: HTH transcriptional regulator, MerR; SPTR: Transcriptional regulator, MerR family.
  
 
 0.613
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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