STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AEJ61328.1Metal dependent phosphohydrolase; PFAM: HD domain; TIGRFAM: putative HD superfamily hydrolase of NAD metabolism; COGs: COG1713 HD superfamily hydrolase involved in NAD metabolism; InterPro IPR006674:IPR005249:IPR003607; KEGG: rxy:Rxyl_2559 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; SMART: Metal-dependent phosphohydrolase, HD region; SPTR: Metal dependent phosphohydrolase; TIGRFAM: Conserved hypothetical protein CHP00488. (185 aa)    
Predicted Functional Partners:
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
  
 0.967
rsfS
Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
  
    0.922
obg
GTPase obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  
    0.815
AEJ61329.1
Membrane-bound protein LytR; PFAM: Cell envelope-related transcriptional attenuator domain; COGs: COG1316 Transcriptional regulator; KEGG: sta:STHERM_c10310 membrane-bound protein LytR; SPTR: Putative uncharacterized protein.
       0.811
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
       0.775
AEJ61324.1
PFAM: Protein of unknown function (DUF464); COGs: COG2868 ribosomal protein; InterPro IPR007422; KEGG: sta:STHERM_c10270 hypothetical protein; PFAM: Protein of unknown function DUF464; SPTR: Putative uncharacterized protein.
  
    0.775
rpmA
PFAM: Ribosomal L27 protein; TIGRFAM: ribosomal protein L27; COGs: COG0211 Ribosomal protein L27; HAMAP: Ribosomal protein L27; InterPro IPR001684; KEGG: sta:STHERM_c10280 50S ribosomal protein L27; PFAM: Ribosomal protein L27; SPTR: 50S ribosomal protein L27; TIGRFAM: Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.
       0.775
aroE
3-dehydroquinate dehydratase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
    0.615
AEJ61321.1
PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: sta:STHERM_c10240 glutamate synthase; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; SPTR: Glutamate synthase (NADH) large subunit.
       0.579
AEJ61322.1
Glutamate synthase, NADH/NADPH, small subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: sta:STHERM_c10250 hypothetical protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Glutamate synthase (NADH) small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1.
       0.572
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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