Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61344.1PDZ/DHR/GLGF domain protein; PFAM: Trypsin; PDZ domain (Also known as DHR or GLGF); COGs: COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain; InterPro IPR001254:IPR001478; KEGG: sta:STHERM_c10450 trypsin domain/PDZ domain-containing protein; PFAM: PDZ/DHR/GLGF; Peptidase S1/S6, chymotrypsin/Hap; SMART: PDZ/DHR/GLGF; SPTR: PDZ/DHR/GLGF domain protein. (590 aa)    
Predicted Functional Partners:
rplY
50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
   
   0.787
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 
 0.775
AEJ61343.1
KEGG: sta:STHERM_c10440 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
tilS
tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
  
    0.761
pth
Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
       0.744
AEJ61345.1
KEGG: sta:STHERM_c10460 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.541
AEJ61247.1
PFAM: Ankyrin repeat; COGs: COG0666 FOG: Ankyrin repeat; InterPro IPR002110; KEGG: sta:STHERM_c09480 ankyrin repeat-containing protein; PFAM: Ankyrin repeat; SMART: Ankyrin repeat; SPTR: Ankyrin.
  
 0.519
AEJ61346.1
PUR-alpha/beta/gamma DNA/RNA-binding protein; PFAM: Protein of unknown function (DUF3276); InterPro IPR006628; KEGG: sta:STHERM_c10470 hypothetical protein; SMART: PUR-alpha/beta/gamma, DNA/RNA-binding; SPTR: Putative uncharacterized protein.
   
   0.501
spoVG
Septation protein spoVG; Could be involved in septation.
       0.490
rpsF
30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
 
 
 
 0.485
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.