STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AEJ61394.1Adenylate/guanylate cyclase with Chase sensor; PFAM: Adenylate and Guanylate cyclase catalytic domain; CHASE2 domain; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR007890:IPR001054; KEGG: sta:STHERM_c10940 hypothetical protein; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with Chase sensor. (787 aa)    
Predicted Functional Partners:
AEJ62063.1
PFAM: Nucleoside diphosphate kinase; COGs: COG0105 Nucleoside diphosphate kinase; InterPro IPR001564; KEGG: sta:STHERM_c17330 nucleoside-diphosphate kinase; PFAM: Nucleoside diphosphate kinase, core; SMART: Nucleoside diphosphate kinase, core; SPTR: Nucleoside diphosphate kinase; Belongs to the NDK family.
    
 0.908
AEJ61728.1
PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144:IPR012833; KEGG: sta:STHERM_c06820 anaerobic ribonucleoside triphosphate reductase; PFAM: ATP-cone; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic.
     
  0.900
AEJ62234.1
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
  0.900
ribBA
GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.805
folE2
Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate.
     
  0.800
AEJ62120.1
Putative transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595; KEGG: sta:STHERM_c18210 transcriptional regulatory protein; PFAM: Cyclic nucleotide-binding; SMART: Cyclic nucleotide-binding; SPTR: Putative transcriptional regulator, Crp/Fnr family.
 
 0.799
AEJ60459.1
Putative transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595; KEGG: sta:STHERM_c01880 transcriptional regulatory protein; PFAM: Cyclic nucleotide-binding; SMART: Cyclic nucleotide-binding; SPTR: Putative transcriptional regulator, Crp/Fnr family.
 
 0.797
AEJ61392.1
KEGG: sta:STHERM_c10920 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
AEJ61393.1
KEGG: sta:STHERM_c10930 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
AEJ61377.1
Hypothetical protein; PFAM: Metallo-beta-lactamase superfamily; COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; KEGG: sta:STHERM_c10770 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.765
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.