STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61423.1PFAM: Histidine kinase; COGs: COG3920 Signal transduction histidine kinase; InterPro IPR003660:IPR011495; KEGG: sta:STHERM_c11210 hypothetical protein; PFAM: Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor region; HAMP linker domain; SPTR: Signal transduction histidine kinase. (617 aa)    
Predicted Functional Partners:
AEJ62092.1
PFAM: Histidine kinase; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG3920 Signal transduction histidine kinase; InterProIPR001789:IPR013767:IPR011495:IPR003594:IPR 000014; KEGG: sta:STHERM_c17620 sensor histidine kinase; PFAM: ATP-binding region, ATPase-like; PAS fold; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor region; SMART: Signal transduction response regulator, receiver region; PAS; ATP-binding [...]
 
   
 0.791
AEJ62414.1
Putative signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG3920 Signal transduction histidine kinase; InterPro IPR003594; KEGG: sta:STHERM_c21140 signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like; SMART: ATP-binding region, ATPase-like; SPTR: Putative signal transduction histidine kinase.
  
     0.769
AEJ61016.1
PFAM: Response regulator receiver domain; InterPro IPR001789; KEGG: sta:STHERM_c14860 hypothetical protein; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver.
  
   
 0.766
AEJ60303.1
PFAM: Response regulator receiver domain; PAS fold; COGs: COG0784 FOG: CheY-like receiver; InterPro IPR001789; KEGG: sta:STHERM_c00160 transcriptional regulatory protein; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver protein.
 
   
 0.753
AEJ61427.1
PFAM: Surface antigen variable number repeat; Surface antigen; TIGRFAM: outer membrane protein assembly complex, YaeT protein; COGs: COG4775 Outer membrane protein/protective antigen OMA87; InterPro IPR010827:IPR000184:IPR016474; KEGG: sta:STHERM_c11250 surface antigen; PFAM: Bacterial surface antigen (D15); Surface antigen variable number; SPTR: Outer membrane protein assembly complex, YaeT protein; TIGRFAM: Outer membrane assembly protein, YaeT.
  
    0.596
AEJ61422.1
MULE transposase, conserved domain-containing protein; Required for the transposition of the insertion element.
       0.576
mutS
DNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
       0.554
AEJ61424.1
Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein; COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: sta:STHERM_c11220 hypothetical protein; PFAM: Phosphoribosyltransferase; SPTR: Putative uncharacterized protein; manually curated.
       0.545
AEJ60715.1
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; Response regulator receiver domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000014:IPR000160:IPR001789:IPR001633:IPR 013767; KEGG: sta:STHERM_c04670 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Signal transduction response regulator, receiver region; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclas [...]
 
   
 0.487
AEJ61409.1
PBS lyase HEAT domain protein repeat-containing protein; PFAM: PBS lyase HEAT-like repeat; HEAT repeat; COGs: COG1413 FOG: HEAT repeat; InterPro IPR004155; KEGG: sta:STHERM_c11080 PBS lyase heat-like repeat domain-containing protein; PFAM: PBS lyase HEAT-like repeat; SMART: PBS lyase HEAT-like repeat; SPTR: PBS lyase HEAT domain protein repeat-containing protein.
 
     0.484
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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