Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ61439.1PEGA domain protein; PFAM: Formylglycine-generating sulfatase enzyme; PEGA domain; COGs: COG1262 conserved hypothetical protein; InterPro IPR013229:IPR005532; KEGG: sta:STHERM_c11370 hypothetical protein; PFAM: PEGA; Sulphatase-modifying factor; SPTR: PEGA domain protein. (550 aa)    
Predicted Functional Partners:
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
     
 0.809
AEJ61591.1
PFAM: Bacterial alpha-L-rhamnosidase; Alpha-L-rhamnosidase N-terminal domain; InterPro IPR013737:IPR008902; KEGG: sta:STHERM_c08460 alfa-L-rhamnosidase; PFAM: Bacterial alpha-L-rhamnosidase; Bacterial alpha-L-rhamnosidase N-terminal; SPTR: Alpha-L-rhamnosidase.
  
   0.743
AEJ61438.1
PFAM: Peptidase S24-like; TIGRFAM: signal peptidase I, bacterial type; COGs: COG0681 Signal peptidase I; InterPro IPR019759:IPR000223; KEGG: sta:STHERM_c11360 signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region; SPTR: Signal peptidase I; TIGRFAM: Peptidase S26A, signal peptidase I.
 
     0.674
AEJ61441.1
Tetratricopeptide TPR_2 repeat-containing protein; PFAM: Bacterial transcriptional activator domain; Tetratricopeptide repeat; COGs: COG5010 Flp pilus assembly protein TadD contains TPR repeats; InterPro IPR001440:IPR013105:IPR019734; KEGG: sta:STHERM_c11390 hypothetical protein; PFAM: Tetratricopeptide TPR2; Tetratricopeptide TPR-1; SPTR: Tetratricopeptide TPR_1 repeat-containing protein; tmRNA as predicted by Rfam (RF00023), score 155.20.
       0.619
AEJ61436.1
Oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: putative oxygen-independent coproporphyrinogen III oxidase; COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR004559:IPR006638; KEGG: sta:STHERM_c11340 oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM; HemN, C-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: Putative oxygen-independent coproporphyrinogen III oxidase.
       0.562
AEJ61437.1
TIGRFAM: signal peptidase I, bacterial type; InterPro IPR019759:IPR000223; KEGG: sta:STHERM_c11350 hypothetical protein; PFAM: Peptidase S24/S26A/S26B, conserved region; SPTR: Signal peptidase I; TIGRFAM: Peptidase S26A, signal peptidase I.
       0.555
AEJ61626.1
Protein of unknown function YGGT; PFAM: YGGT family; InterPro IPR003425; KEGG: sta:STHERM_c08080 hypothetical protein; PFAM: Protein of unknown function YGGT; SPTR: Putative uncharacterized protein.
 
     0.494
AEJ62522.1
Glycoside hydrolase family 37; PFAM: Trehalase; COGs: COG1626 Neutral trehalase; InterPro IPR001661; KEGG: sta:STHERM_c22220 hypothetical protein; PFAM: Glycoside hydrolase, family 37; SPTR: Glycoside hydrolase family 37.
  
     0.476
AEJ60544.1
PFAM: Uncharacterised protein family (UPF0158); KEGG: sta:STHERM_c02740 hypothetical protein; SPTR: Putative uncharacterized protein.
  
  
 0.455
AEJ61435.1
UPF0082 protein yeeN; PFAM: Domain of unknown function DUF28; TIGRFAM: DNA-binding regulatory protein, YebC/PmpR family; COGs: COG0217 conserved hypothetical protein; HAMAP: Protein of unknown function DUF28; InterPro IPR002876; KEGG: sta:STHERM_c11330 hypothetical protein; PFAM: Protein of unknown function DUF28; SPTR: UPF0082 protein SpithDRAFT_0598; TIGRFAM: Protein of unknown function DUF28.
       0.414
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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