STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61480.1PFAM: N-6 DNA Methylase; HsdM N-terminal domain; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR003356; KEGG: sin:YN1551_3201 N-6 DNA methylase; PFAM: DNA methylase, adenine-specific; SPTR: N-6 DNA methylase. (552 aa)    
Predicted Functional Partners:
AEJ61484.1
PFAM: Domain of unknown function (DUF3387); COGs: COG0610 Type I site-specific restriction-modification system R (restriction) subunit and related helicase; KEGG: mrb:Mrub_2450 type I site-specific deoxyribonuclease HsdR family; SPTR: Type I site-specific deoxyribonuclease HsdR family.
 
 
 0.999
AEJ61479.1
PFAM: Type I restriction enzyme R protein N terminus (HSDR_N); Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; COGs: COG4096 Type I site-specific restriction-modification system R (restriction) subunit and related helicase; InterPro IPR007409:IPR006935:IPR001650:IPR014001; KEGG: cpo:COPRO5265_1439 type I restriction-modification system, R subunit; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; DNA/RNA helicase, C-terminal; SMART: DEAD-like heli [...]
 
 
 0.996
AEJ61482.1
PFAM: Type I restriction modification DNA specificity domain; COGs: COG0732 Restriction endonuclease S subunits; InterPro IPR000055; KEGG: tte:TTE1545 restriction endonuclease S subunits; PFAM: Restriction endonuclease, type I, S subunit, EcoBI; SPTR: Restriction modification system DNA specificity domain.
 
 
 0.992
AEJ61478.1
PFAM: N-6 DNA Methylase; HsdM N-terminal domain; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR003356; KEGG: cyj:Cyan7822_0692 adenine-specific DNA-methyltransferase; PFAM: DNA methylase, adenine-specific; SPTR: Site-specific DNA-methyltransferase (Adenine-specific).
 
 
0.977
AEJ61483.1
PFAM: Protein of unknown function (DUF3644); KEGG: cte:CT1443 hypothetical protein; SPTR: Putative uncharacterized protein.
  
    0.969
AEJ61481.1
PFAM: PIN domain; InterPro IPR002716; PFAM: PilT protein, N-terminal; SPTR: PilT protein domain protein.
       0.773
AEJ61477.1
KEGG: tai:Taci_1496 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.767
AEJ60608.1
PFAM: Domain of unknown function (DUF814); Fibronectin-binding protein A N-terminus (FbpA); COGs: COG1293 RNA-binding protein homologous to eukaryotic snRNP; InterPro IPR008616:IPR008532; KEGG: sta:STHERM_c03370 fibronectin-binding protein; PFAM: Protein of unknown function DUF814; Fibronectin-binding A, N-terminal; SPTR: Putative uncharacterized protein.
  
    0.659
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.587
AEJ62480.1
Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; COGs: COG0560 Phosphoserine phosphatase; InterPro IPR011863:IPR005834; KEGG: sta:STHERM_c21790 hypothetical protein; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: Phosphoserine:homoserine phosphotransferase; phosphoserine phosphatase; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferas [...]
  
  
 0.506
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.