STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61487.1PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family; AraC-type transcriptional regulator N-terminus; COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR009594:IPR000005:IPR018060; KEGG: sta:STHERM_c11750 transcriptional regulator, AraC family; PFAM: AraC-type transcriptional regulator, N-terminal; Helix-turn-helix, AraC type; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family. (303 aa)    
Predicted Functional Partners:
AEJ61488.1
PFAM: Aldo/keto reductase family; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395; KEGG: sta:STHERM_c11760 aldo/keto reductase; PFAM: Aldo/keto reductase; SPTR: Aldo/keto reductase.
 
     0.743
AEJ62404.1
PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family; AraC-like ligand binding domain; COGs: COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain; InterPro IPR003313:IPR000005:IPR018060; KEGG: sta:STHERM_c21040 transcriptional regulatory protein; PFAM: AraC protein, arabinose-binding/dimerisation; Helix-turn-helix, AraC type; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
 
 
0.720
AEJ61587.1
PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR018060:IPR000005; KEGG: sta:STHERM_c08500 transcriptional regulatory protein; PFAM: Helix-turn-helix, AraC type; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
 
 
 0.674
AEJ61486.1
KEGG: sta:STHERM_c11740 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.642
AEJ60641.1
PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR018060:IPR000005; KEGG: sta:STHERM_c03910 transcriptional regulator, AraC family; PFAM: Helix-turn-helix, AraC type; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
 
 
 0.630
AEJ60652.1
Transcriptional regulator with cupin sensor, AraC family; PFAM: AraC-like ligand binding domain; Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR018060:IPR013096:IPR000005; KEGG: sta:STHERM_c04010 transcriptional regulator, AraC/XylS family; PFAM: Helix-turn-helix, AraC type; Cupin 2, conserved barrel; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
 
 
0.600
AEJ61043.1
Transcriptional regulator, AraC family; PFAM: Cupin domain; Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR000005:IPR018060; KEGG: sta:STHERM_c14630 transcriptional regulatory protein; PFAM: Helix-turn-helix, AraC type; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
 
 
 0.600
AEJ60993.1
PFAM: Iron-containing alcohol dehydrogenase; COGs: COG1979 Uncharacterized oxidoreductase Fe-dependent alcohol dehydrogenase family; InterPro IPR001670; KEGG: sta:STHERM_c15070 hypothetical protein; PFAM: Alcohol dehydrogenase, iron-type; SPTR: Iron-containing alcohol dehydrogenase.
  
    0.556
AEJ62109.1
Hypothetical protein; PFAM: NmrA-like family; COGs: COG0702 nucleoside-diphosphate-sugar epimerase; InterPro IPR008030; KEGG: sta:STHERM_c17810 hypothetical protein; SPTR: NmrA family protein.
 
    0.434
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
 
 0.418
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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